BioCentury | Apr 3, 2020
Distillery Therapeutics

The bacterial adhesion protein fimH as a cancer immunotherapy adjuvant

...fimH could be used as an adjuvant for cancer immunotherapy. In mice modeling melanoma, administering fimH...
...In mice with colorectal cancer or melanoma expressing the self-antigens AH1A5 or DCT, E. coli fimH...
...growth and increased IFNγ production in tumor-draining lymph nodes. Also in the colorectal cancer model, fimH...
BioCentury | Oct 26, 2018
Company News

Takeda licenses Enterome's Crohn's disease therapy

...Enterome will be responsible for the remaining 25%. EB8018, an inhibitor of inflammation mediated by bacterial fimbrial adhesin (fimH)...
...include other gastrointestinal or liver diseases; Belichard said the partners will explore indications in which fimH-expressing...
...Ltd. (Tokyo:4502), Tokyo, Japan Business: Autoimmune Sandi Wong EB8018, EP8018, ep-8018 Enterome Bioscience S.A. Takeda Pharmaceutical Co. Ltd. Vertex Pharmaceuticals Inc. Bacterial fimbrial adhesin (fimH) Crohn's...
BioCentury | Oct 23, 2018
Company News

Takeda licenses Enterome's Crohn's disease therapy

...Enterome will be responsible for the remaining 25%. EB8018, an inhibitor of inflammation mediated by bacterial fimbrial adhesin (fimH)...
...include other gastrointestinal or liver diseases; Belichard said the partners will explore indications in which fimH-expressing...
...Deal with Microbiome Play Enterome" ). Sandi Wong EB8018, EP8018, ep-8018 Enterome Bioscience S.A. Takeda Pharmaceutical Co. Ltd. Vertex Pharmaceuticals Inc. Bacterial fimbrial adhesin (fimH) Crohn's...
BioCentury | Jan 5, 2018
Financial News

Microbiome company Enterome raises €32M

...European Investment Bank. The company’s lead programs are EB8018, an oral small molecule antagonist of bacterial fimbrial adhesin (fimH)...
...July 14, 2017 ). Enterome Bioscience S.A., Paris, France Jaime De Leon EB8018 Bristol-Myers Squibb Co. Enterome Bioscience S.A. Nestle S.A. Bacterial fimbrial adhesin (fimH) EO2315...
BioCentury | Jan 4, 2018
Financial News

Microbiome company Enterome raises €32M

...European Investment Bank. The company’s lead programs are EB8018, an oral small molecule antagonist of bacterial fimbrial adhesin (fimH)...
...NAFLD) (see BioCentury, July 14, 2017) . Jaime De Leon EB8018 EP8018 Bristol-Myers Squibb Co. Enterome Bioscience S.A. European Investment Bank Nestle S.A. Bacterial fimbrial adhesin (fimH) EO2315...
BioCentury | Nov 30, 2017
Clinical News

Enterome's CD candidate well tolerated in Phase I

...microbiome richness. Enterome is planning to begin a Phase Ib trial of the small molecule bacterial fimbrial adhesin (fimH)...
...plans to begin a Phase II trial. Enterome has exclusive, worldwide rights to small molecule fimH...
...Product: EB8018, EP8018 (formerly EP-8018) Business: Autoimmune Molecular target: Bacterial fimbrial adhesin (fimH) Description: Small molecule antagonist of fimH...
BioCentury | Jan 12, 2017
Clinical News

EB8018: Ph I started

...EB8018, EB 8018 (formerly EP-8018) Business: Autoimmune Molecular target: Bacterial fimbrial adhesin (fimH) Description: Small molecule antagonist of fimH...
...pharmacokinetics and microbiome richness Status: Phase I started Milestone: NA Julian Zhu EB 8018 Enterome Bioscience S.A. Vertex Pharmaceuticals Inc. Bacterial fimbrial adhesin (fimH) EB8018...
BioCentury | Nov 5, 2016
Finance

Vive la biotech

...trial for lead candidate EB 8018 , a small molecule antagonist of bacterial fimbrial adhesion (fimH...
BioCentury | May 9, 2016
Product Development

Community organizers

...preclinical testing to treat Crohn's disease. EB 8018 targets adherent-invasive E. coli (AIEC) by antagonizing bacterial fimbrial adhesin (fimH)...
...AIEC contributes to chronic inflammation by secreting pro-inflammatory factors like tumor necrosis factor (TNF) . fimH...
...inflammation Preclin Start clinical testing 4Q16/1Q17 Enterome Bioscience S.A. EB 8018 Small molecule antagonist of bacterial fimbrial adhesin (fimH)...
BioCentury | May 2, 2016
Company News

Vertex, Enterome Bioscience deal

...Vertex granted Enterome exclusive, worldwide rights to small molecule antagonists of bacterial fimbrial adhesin (fimH) , including lead compound...
...indication in combination with a companion diagnostic to identify IBD patients who will benefit from fimH...
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