22:07 , Sep 13, 2018 |  BC Innovations  |  Translation in Brief

New Therapeutic Targets and Biomarkers: August 2018

New Therapeutic Targets and Biomarkers: August 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database in August 2018. Therapeutic targets are defined as any protein, gene or other...
23:48 , Aug 8, 2018 |  BC Innovations  |  Distillery Therapeutics

Cardiovascular

INDICATION: Thrombosis In vitro , cell culture and mouse studies identified a choline-based inhibitor of bacterial cutC that could help treat thrombosis. Chemical synthesis of choline analogs, and in vitro and bacterial cell-based enzymatic activity...
20:38 , Aug 6, 2018 |  BC Extra  |  Preclinical News

Modifying microbes for clot prevention

Cleveland Clinic researchers have developed inhibitors of bacterial choline trimethylamine-lyase (bacterial cutC), an enzyme found in commensal gut microbes, that could help treat thrombosis by targeting bacterial metabolic activity without killing the microbes. Previous studies...