20:01 , Jun 20, 2019 |  BC Innovations  |  Translation in Brief

Turning Tregs against cancer

Researchers from Massachusetts General Hospital found that inhibiting a signalosome complex in Treg cells could convert the immunosuppressive cell type into inflammatory cells in tumors, a strategy that could both increase the efficacy of checkpoint...
20:39 , Jun 11, 2019 |  BC Innovations  |  Distillery Therapeutics

Inhibiting BCL10 or MALT1 for melanoma

DISEASE CATEGORY: Cancer INDICATION: Melanoma Mouse studies suggest inhibiting BCL10 or MALT1 could help treat melanoma. In a syngeneic mouse model of melanoma, Treg-specific knockout of BCL10 decreased tumor size compared with normal BCL10 expression....
17:57 , May 16, 2017 |  BC Innovations  |  Distillery Techniques

Biomarkers

TECHNOLOGY: Gene profiling Tumor levels of eight proteins could help predict survival in melanoma. In patients, low tumor levels of eight tumor suppressors -- tumor necrosis factor α-induced protein 3 ( TNFAIP3 ; A20), PR...
07:00 , Sep 5, 2013 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

Approach Summary Licensing status Publication and contact information Drug platforms Small molecules that prevent teratoma formation in human pluripotent stem cell-derived therapies Small molecules that are selectively toxic to human pluripotent stem cells could help...