BioCentury | Dec 6, 2019
Targets & Mechanisms

Emerging immuno-oncology mechanisms at ASH 2019

...expansion will perform in CLL patients. Another emerging T cell inhibitory protein, the checkpoint protein BTLA...
...abstracts describe manipulation of BTLA as a therapeutic target, at least two companies are developing anti-BTLA...
...cells (see “NK Cell Check-in” ). Targets AMPD1 - Adenosine monophosphate deaminase 1 BTLA - B and T lymphocyte attenuator...
BioCentury | Oct 6, 2016
Product R&D

Local sensitivity

...Md. Targets and Compounds IL-2 - Interleukin-2 IL-10 - Interleukin-10 IL-12 - Interleukin-12 BTLA - B and T lymphocyte attenuator...
...in germinal center B cell lymphomas, and its loss of function disrupts its interaction with BTLA...
BioCentury | Jan 29, 2015
Strategy

PD-1 matchmaking

...co-stimulators apart from PD-1 and CTLA-4. Co-inhibitor targets that are gaining prominence include TIGIT , BTLA...
...Tesaro Inc. (NASDAQ:TSRO), Waltham, Mass. University of Pennsylvania, Philadelphia, Pa. Targets and Compounds BTLA - B and T lymphocyte attenuator...
BioCentury | Jan 30, 2014
Distillery Therapeutics

Indication: Autoimmune disease

...and contact information Autoimmune disease Psoriasis B and T lymphocyte attenuator (BTLA) Cell culture and mouse studies suggest agonizing BTLA...
...could help treat psoriasis. In a subset of cultured gd T cells treated with Il-7, Btla...
...tumor necrosis factor (TNF) production than wild-type cells. In a mouse model of acute dermatitis, Btla...
BioCentury | Dec 9, 2010
Distillery Therapeutics

Indication: Transplantation

...Transplantation Graft-versus-host disease (GvHD) B and T lymphocyte attenuator (BTLA) Studies in mice suggest that an agonist mAb targeting BTLA...
...help prevent GvHD. In a mouse model of allogeneic hematopoietic stem cell transplantation, an agonistic BTLA-targeting...
...against BTLA. SciBX 3(47); doi:10.1038/scibx.2010.1422 Published online Dec. 9, 2010 Multiple patent applications filed covering BTLA...
BioCentury | Jan 31, 2008
Distillery Therapeutics

This Week in Therapeutics

...response and boosting vaccine efficacy In vitro and in vivo studies suggest that preventing B and T lymphocyte attenuator (BTLA...
...Fusion of viral antigens to the C-terminal domain of HSV glycoprotein D (gD), which blocks HVEM-BTLA...
...HPV-16: E7, E6 and E5 (gD-E7E6E5). Next steps include studies to determine if targeting the HMEV-BTLA...
Items per page:
1 - 6 of 6