23:05 , Jan 18, 2018 |  BC Innovations  |  Translation in Brief

A notch for tankyrase

New York University School of Medicine researchers have identified a multitude of tankyrase targets, including factors in the Notch and Wnt/β-catenin pathways, that offer new opportunities for tankyrase inhibitors in cancer. In a Nature Communications...
07:00 , Oct 3, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer b-Catenin (CTNNB1); B cell lymphoma 2 (BCL-2; BCL2); AXIN1; casein kinase 1a (CSNK1A1; CKI-a) In vitro studies suggest mutations in CTNNB1 or in genes...
07:00 , Oct 3, 2013 |  BC Innovations  |  Strategy

The Broad's outlook in cancer

When the Broad Institute of MIT and Harvard launched its Center for the Science of Therapeutics to develop new therapies for hard-to-hit targets and test them in the clinic, it lacked funds to take discoveries...