BioCentury | Jan 18, 2018
Translation in Brief

A notch for tankyrase

...E3 ubiquitin protein ligase 1 (HECTD1). Two established targets of tankyrases in the pathway -- AXIN1...
...of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation.” Nature Communications (2017) Mark Zipkin, Staff Writer BMS-906024 BMS-986115 LY3039478 Lynparza nirogacestat RO4929097 AXIN1 Beta-catenin...
BioCentury | Sep 15, 2016
Targets & Mechanisms

KOR-recting MS

Although the failed Phase II multiple sclerosis trial of Biogen Inc. 's anti-LINGO mAb in June dealt a blow to myelin repair, a slew of compounds acting by different mechanisms lies behind it in clinical...
BioCentury | Oct 3, 2013
Distillery Therapeutics

Indication: Cancer

...status Publication and contact information Cancer Cancer b-Catenin (CTNNB1); B cell lymphoma 2 (BCL-2; BCL2); AXIN1...
...treated cancer cell lines also identified correlations between sensitivity to navitoclax and loss-of-function mutations in AXIN1...
BioCentury | Oct 3, 2013
Strategy

The Broad's outlook in cancer

...cell lines. The study also revealed correlations between sensitivity to navitoclax and loss-of-function mutations in AXIN1...
...CSNK1A1 ; CKI- a), which play roles in CTNNB1 degradation. Thus, mutations in CTNNB1 , AXIN1...
BioCentury | Apr 18, 2013
Cover Story

Targeting tankyrase

Researchers from the University of Oslo and Roche 's Genentech Inc. unit have developed several selective inhibitors of tankyrases TNKS and TNKS2 , two druggable targets in the otherwise hard-to-hit WNT pathway. 1,2 The University team's...
BioCentury | Sep 24, 2009
Targets & Mechanisms

Clearing the path to Wnt

Despite the clear involvement of the Wnt pathway in cancer, 1,2 there are no disclosed inhibitors of Wnt signaling in the clinic. The reasons are twofold: the pathway is almost entirely intracellular and most of...
BioCentury | Dec 24, 2001
Company News

Chiron other research news

Scientists reported in the Proceedings of the National Academy of Sciences evidence that the genes axin2 and hnkd could be used as biomarkers for activation of the Beta-catenin pathway, which is involved in tumorigenesis, in...
Items per page:
1 - 7 of 7