08:00 , Mar 3, 2011 |  BC Innovations  |  Targets & Mechanisms

Targeting T cell metabolism

Researchers at the University of Michigan have shown that modulating ATP synthase activity can selectively kill alloreactive T cells and arrest graft-versus-host disease. 1 Lycera Corp. has licensed the findings, which may provide a new...
08:00 , Feb 24, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Transplantation

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Transplantation Graft-versus-host disease (GvHD) ATP synthase H+ transporting mitochondrial F1 complex O subunit (ATP5O; OSCP) Studies in mice suggest that inhibiting ATP5O...