BioCentury | Sep 18, 2020

With details on lead sialoglycan degrader in place, Palleon raises $100M series B

Having nominated a lead program, identified top indications and sorted out manufacturing, Palleon raised a $100 million series B round to bring its enzymatic sialoglycan degrader to the clinic for cancer....
BioCentury | Aug 27, 2020
Distillery Therapeutics

A collagen receptor as an Alzheimer’s target

DISEASE CATEGORY: Neurology INDICATION: Alzheimer’s disease (AD) Blocking the collagen receptor GP6 could treat Alzheimer’s disease by reducing platelet-associate β amyloid aggregation. In vitro, platelets...
BioCentury | Jul 23, 2020

Elevation debuts with tumor-agnostic mAb in Phase II

Led by former Loxo Chairman Steve Elms, Elevation emerged from stealth Tuesday with a registration-enabling trial of a tissue-agnostic cancer therapy and a handful of diagnostics partners. Elevation Oncology Inc. is developing therapies for cancers...
BioCentury | Jul 15, 2020
Product Development

Repurposing hopes for Tavalisse in COVID-19 breathe life into Rigel shares

Rigel is the latest beneficiary of investor exuberance for COVID-19 plays. Shares of Rigel Pharmaceuticals Inc. (NASDAQ:RIGL) gained 91% to $4.12, giving the company a market cap of nearly $700 million, after it said on...
BioCentury | Jul 3, 2020

On heels of $100M raise, Annexon joins burgeoning IPO queue

Two days after raising $100 million in a series D round heavy with crossover investors, Annexon has filed to go public on NASDAQ. The filing adds to a burgeoning IPO queue and caps another busy...
BioCentury | Jun 4, 2020
Product Development

June 3 Quick Takes: Double double for BeiGene’s Brukinsa; plus Novartis, Merck-Vaxxas, Antibe, Mirum and more

BeiGene’s BTK inhibitor gets first China approval BeiGene Ltd. (NASDAQ:BGNE; HKEX:6160) said China’s National Medical Products Administration approved Brukinsa zanubrutinib in two cancer indications: chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) and mantle cell lymphoma...
BioCentury | May 9, 2020
Translation in Brief

Antigens for COVID-19 serological testing; plus mapping glycans on SARS-CoV-2 spike, tumor sampling method and therapy for Parkinson’s

SARS-CoV-2 antigens beyond the spike protein Described in a medRxiv preprint, researchers from the University of Hong Kong identified SARS-CoV-2 antigens beyond the spike protein that could be used to detect antibodies at early time...
BioCentury | Apr 11, 2020
Emerging Company Profile

Clover: trimerizing fusion proteins

Clover is developing trimerized fusion proteins to target cancer and infectious disease pathways that depend on trimer formation. The company has exclusive, worldwide rights to its Trimer-Tag platform from GenHunter Corp., which was co-founded by...
BioCentury | Apr 9, 2020
Product Development

April 8 COVID-19 roundup: National Academy of Sciences says COVID-19 could continue through summer; plus HHS, SAb-CSL, Vanda-UIC, Avacta-Cytiva and more

As companies and academic groups continue to form new partnerships and identify new drug targets to combat COVID-19, a National Academy of Sciences committee has warned there’s no guarantee the pandemic will be completely contained...
BioCentury | Feb 28, 2020
Distillery Therapeutics

Sudan ebolavirus glycoprotein-targeting mAbs to treat Sudan virus infection

DISEASE CATEGORY: Infectious disease INDICATION: Ebola A cocktail of two mAbs targeting the Sudan ebolavirus glycoprotein could treat infection by the virus. Identification of the antibody combination involved screening antibody libraries derived from mice and...
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