20:56 , Dec 19, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Melanoma Mouse studies suggest inhibiting ATG7 or ATG5 could help treat melanoma. In a xenograft mouse model of melanoma, systemic or liver-specific knockout of ATG7 decreased tumor growth compared with normal ATG7 expression, and...
16:05 , Aug 16, 2018 |  BC Innovations  |  Distillery Therapeutics

Autoimmune disease

INDICATION: Arthritis; multiple sclerosis (MS) Cell culture and mouse studies suggest inhibiting autophagy in T cells could treat juvenile idiopathic arthritis (JIA), MS and other autoimmune diseases. In activated primary CD4 + T cells from...
18:51 , May 30, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Breast cancer Cell culture and mouse studies suggest inhibiting autophagy could treat breast cancer metastasis arising from dormant tumor cells. In human breast cancer cell lines, autophagy was higher in a dormant cell line...
00:23 , Feb 3, 2017 |  BC Innovations  |  Targets & Mechanisms

Eating healthy

While pharma is still treading carefully in the field of autophagy, unsure of its use in cancer, Deerfield Management Corp. L.P. has decided the time is right to invest in the emerging translational opportunities. The...
07:00 , Aug 13, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: ATG7 autophagy related 7 homolog (ATG7)

Cancer INDICATION: Colorectal cancer Mouse studies suggest inhibiting ATG7 while maintaining commensal gut bacteria could help prevent colorectal cancer. In a mouse model of spontaneous colorectal cancer, ATG7 knockout in intestinal epithelial cells increased the...
08:00 , Feb 5, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: ATG7 autophagy related 7 homolog (ATG7)

Other INDICATION: Adjuvant In vitro and mouse studies suggest spermidine or its analogs could improve CD8+ T memory cell responses to vaccination in the elderly. In T memory cells from mice, levels of ATG7 mRNA,...
07:00 , Jul 17, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Lung cancer ATG7 autophagy related 7 homolog (ATG7) Mouse studies suggest acute inhibition of autophagy could be useful for treating lung cancer. In a mouse...
08:00 , Mar 3, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Cancer Cancer ATG5 autophagy related 5 homolog (ATG5); ATG7 autophagy related 7 homolog (ATG7); Ras Studies in mice and in cell...
07:00 , Oct 22, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Endocrine disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine disease Obesity ATG7 autophagy-related 7 homolog (ATG7) A study in mice suggests that inhibiting ATG7 in adipose tissue could be useful for treating obesity. In...