BioCentury | Dec 19, 2018
Distillery Therapeutics

Cancer

...include identifying small molecule ATG7 and ATG5 inhibitors and testing them in the model. TARGET/MARKER/PATHWAY: ATG7 autophagy related 7 homolog (ATG7)...
...CONTACT: Eileen White, Rutgers University, Piscataway, N.J. email: epwhite@cinj.rutgers.edu Chris Lieu Rutgers University ATG5 autophagy related 5 homolog (ATG5) ATG7 autophagy related 7 homolog (ATG7) Melanoma...
BioCentury | Aug 16, 2018
Distillery Therapeutics

Autoimmune disease

...respectively. Next steps could include testing autophagy inhibition in models of other autoimmune diseases. TARGET/MARKER/PATHWAY: ATG7 autophagy related 7 homolog (ATG7)...
...email: e.mocholi-gimeno@umcutrecht.nl CONTACT: Fernando Macian, same affiliation as above email: fernando.macian@einstein.yu.edu Hongjiang Li Albert Einstein College of Medicine ATG7 autophagy related 7 homolog (ATG7) Arthritis...
BioCentury | May 30, 2018
Distillery Therapeutics

Cancer

...to treat ovarian cancer and solid tumors. Generic hydroxychloroquine is marketed to treat malaria. TARGET/MARKER/PATHWAY: ATG7 autophagy related 7 homolog (ATG7)...
...2018 doi:10.1038/s41467-018-04070-6 CONTACT: Kent Hunter, National Cancer Institute, Bethesda, Md. email: hunterk@mail.nih.gov Allison Johnson HCQ, hydroxychloroquine National Cancer Institute ATG7 autophagy related 7 homolog (ATG7) Breast...
BioCentury | Apr 25, 2017
Distillery Therapeutics

Cancer

INDICATION: Non-small cell lung cancer (NSCLC) Cell culture and mouse studies suggest combining inhibitors of CD47 and autophagy could help treat NSCLC. In co-cultures of a human NSCLC cell culture and a mouse macrophage cell...
BioCentury | Feb 3, 2017
Targets & Mechanisms

Eating healthy

...of Texas MD Anderson Cancer Center Vescor LLC ATG3 autophagy related 3 homolog ATG5 autophagy related 5 homolog (ATG5) ATG7 autophagy related 7 homolog (ATG7)...
BioCentury | Aug 13, 2015
Distillery Therapeutics

Therapeutics: ATG7 autophagy related 7 homolog (ATG7)

...in mice compared with no treatment. Next steps could include screening for ATG7 inhibitors. TARGET/MARKER/PATHWAY: ATG7 autophagy related 7 homolog (ATG7)...
BioCentury | Feb 5, 2015
Distillery Therapeutics

Therapeutics: ATG7 autophagy related 7 homolog (ATG7)

...no treatment. Next steps include cell-based screening of spermidine analogs and other autophagy-inducing drugs. TARGET/MARKER/PATHWAY: ATG7 autophagy related 7 homolog (ATG7)...
BioCentury | Aug 14, 2014
Translation in Brief

Translational tidbits

Astellas bites into autophagy Astellas Pharma Inc. and Cancer Research UK announced a two-year research collaboration last week that will initially focus on identifying new drug targets that could block autophagy to treat pancreatic cancer....
BioCentury | Jul 17, 2014
Distillery Therapeutics

Indication: Cancer

...Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Lung cancer ATG7 autophagy related 7 homolog (ATG7) Mouse studies suggest...
BioCentury | Jan 16, 2014
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Pancreatic cancer ATG5 autophagy related 5 homolog (ATG5); ATG7; K-Ras (KRAS); p53 Mouse studies suggest inhibiting autophagy in KRAS-driven pancreatic ductal adenocarcinomas (PDACs) lacking p53...
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