20:56 , Dec 19, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Melanoma Mouse studies suggest inhibiting ATG7 or ATG5 could help treat melanoma. In a xenograft mouse model of melanoma, systemic or liver-specific knockout of ATG7 decreased tumor growth compared with normal ATG7 expression, and...
16:02 , Apr 25, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Non-small cell lung cancer (NSCLC) Cell culture and mouse studies suggest combining inhibitors of CD47 and autophagy could help treat NSCLC. In co-cultures of a human NSCLC cell culture and a mouse macrophage cell...
00:23 , Feb 3, 2017 |  BC Innovations  |  Targets & Mechanisms

Eating healthy

While pharma is still treading carefully in the field of autophagy, unsure of its use in cancer, Deerfield Management Corp. L.P. has decided the time is right to invest in the emerging translational opportunities. The...
07:00 , Aug 14, 2014 |  BC Innovations  |  Translation in Brief

Translational tidbits

Astellas bites into autophagy Astellas Pharma Inc. and Cancer Research UK announced a two-year research collaboration last week that will initially focus on identifying new drug targets that could block autophagy to treat pancreatic cancer....
08:00 , Jan 16, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Pancreatic cancer ATG5 autophagy related 5 homolog (ATG5); ATG7; K-Ras (KRAS); p53 Mouse studies suggest inhibiting autophagy in KRAS-driven pancreatic ductal adenocarcinomas (PDACs) lacking p53...
07:00 , Apr 7, 2011 |  BC Innovations  |  Targets & Mechanisms

Pancreatic cancer: stressed to death

U.S. and EU researchers have shown that the generic malaria drug chloroquine can treat pancreatic cancer by inhibiting autophagy, 1 a process by which cells degrade their own cytosolic components to prolong cell survival. The...
08:00 , Mar 3, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Cancer Cancer ATG5 autophagy related 5 homolog (ATG5); ATG7 autophagy related 7 homolog (ATG7); Ras Studies in mice and in cell...