00:25 , Jun 16, 2018 |  BioCentury  |  Product Development

NSCLC disrupted

This year’s ASCO made clear that PD-1 inhibitors have supplanted chemotherapy as standard of care in first-line metastatic NSCLC. The unanticipated consequence is the knock-on effects for companies with studies under way in both first-...
15:20 , May 9, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer; breast cancer Cell culture and mouse studies identified an imidazoquinolinone-based ATM inhibitor that could help treat colorectal cancer or triple-negative breast cancer (TNBC) in combination with Camptosar irinotecan or Lynparza olaparib, respectively. In...
03:45 , Apr 13, 2018 |  BC Innovations  |  Targets & Mechanisms

Meeting the burden

A major theme at this year’s AACR is the abundance of preclinical discovery driven by molecular signatures in patient samples, suggesting the research community is heeding the call for studies better grounded in human data,...
01:05 , Apr 21, 2017 |  BC Innovations  |  Product R&D

Making marks at AACR

Biomarkers that could stratify patients, point to treatment combinations or predict toxicity were a major part of the conversation at this year’s AACR conference, where they emerged as potential difference makers for a range of...
21:18 , Feb 10, 2017 |  BC Week In Review  |  Company News

Strata, Clovis deal

Strata and Clovis partnered to accelerate patient enrollment in Clovis' TRITON program of Rubraca rucaparib. The program includes Phase II and III trials of Rubraca to treat metastatic castration-resistant prostate cancer. Strata will receive an...
07:00 , Oct 19, 2016 |  BC Extra  |  Company News

Cerulean, Novartis to develop drug conjugates

Cerulean Pharma Inc. (NASDAQ:CERU) gained $0.27 (40%) to $0.95 after announcing a deal with Novartis AG (NYSE:NVS; SIX:NOVN) to develop nanoparticle-drug conjugates (NDCs). The partners will pair Cerulean's Dynamic Tumor Targeting platform with Novartis compounds...
07:00 , Sep 16, 2016 |  BC Extra  |  Financial News

Aerie raises $125M in pair of offerings

Ophthalmic play Aerie Pharmaceuticals Inc. (NASDAQ:AERI) raised a combined $125 million in a follow-on and at-the-market offering. Cantor Fitzgerald is managing both. The biotech raised $75 million through the sale of 2.5 million shares at...
07:00 , Sep 5, 2016 |  BC Week In Review  |  Company News

AstraZeneca, Pfizer deal

Pfizer will acquire AstraZeneca’s small molecule anti-infectives business. The unit includes approved drugs Zavicefta ceftazidime/ avibactam, Zinforo ceftaroline fosamil and Merrem/Meronem meropenam, as well as Phase II candidates, ATM-AVI and ...
07:00 , Sep 1, 2016 |  BC Innovations  |  Distillery Techniques

Techniques: Variants in a panel of 72 genes as risk markers for sarcoma

Biomarkers TECHNOLOGY: Gene profiling Variants in multiple genes associated with other cancers could help predict the risk of sarcoma. In blood and serum samples from three independent cohorts totaling 1,162 sarcoma patients and 6,545 healthy Caucasian volunteers,...
07:00 , Aug 24, 2016 |  BC Extra  |  Company News

Pfizer buying AZ's small molecule anti-infectives business

Pfizer Inc. (NYSE:PFE) is acquiring the small molecule anti-infectives business of AstraZeneca plc (LSE:AZN; NYSE:AZN) for $550 million in cash up front and $175 million due in January 2019. The unit includes approved drugs Zavicefta...