21:37 , Jul 10, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Breast cancer Cell culture studies suggest promoting interactions between miR-34a and tRNA-iMet could help treat breast cancer. In a panel of human breast cancer cell lines, levels of miR-34a were lower and levels of...
02:06 , May 11, 2018 |  BC Innovations  |  Finance

Amplifying oligos

The last five years have seen a steady stream of preclinical deals for antisense, siRNA and mRNA therapies that suggests pharmas are taking the modalities seriously as alternatives to traditional small molecules and antibodies. But...
16:29 , Feb 7, 2018 |  BC Innovations  |  Distillery Techniques

Drug delivery

TECHNOLOGY: Nanoparticles Polyamine-based nanoparticles loaded with AGO2 could be used as delivery vehicles for therapeutic siRNA. The nanoparticles consist of a polyamine capsule containing a therapeutic siRNA and AGO2, an RNA-induced silencing complex (RISC)-interacting protein...
19:11 , Nov 17, 2016 |  BC Innovations  |  Translation in Brief

Point taken

Idera Pharmaceuticals Inc. (NASDAQ:IDRA) has identified an siRNA-like mechanism that may explain the unexpected potency and pinpoint specificity of its third-generation antisense (3GA) DNA technology, which allows for selective silencing of disease-causing alleles. Antisense oligonucleotides...
07:00 , Jun 4, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Argonaute RISC catalytic component 2 (AGO2); fragile X mental retardation autosomal homolog 1 (FXR1)

Autoimmune disease INDICATION: Multiple sclerosis (MS) In vitro studies suggest promoting expression of AGO2 and FXR1 could help treat MS. In CNS tissue, oligodendrocytes and brain-infiltrating T cells from the experimental autoimmune encephalomyelitis (EAE) mouse...
08:00 , Dec 19, 2013 |  BC Innovations  |  Distillery Techniques

Technology: Chemistry

Approach Summary Licensing status Publication and contact information Chemistry Modifications to the siRNA guide strand 5ʹ end that improve therapeutic potency Structure-guided computational screening identified modifications to the guide strand that could improve the therapeutic...
07:00 , Aug 26, 2010 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

This week in techniques Approach Summary Licensing status Publication and contact information Drug platforms Overexpression of exportin 5 (XPO5) and argonaute RISC catalytic component (AG02) to increase the efficacy and safety of small hairpin RNA...