BioCentury | Mar 12, 2015
Distillery Therapeutics

Therapeutics: Arachidonate 12-lipoxygenase (ALOX12; 12-LOX); ALOX15 (15-LOX)

...Neurology INDICATION: Neurology; nerve damage Cell culture and mouse studies suggest inhibiting ALOX12 and ALOX15 could...
...knockout or pharmacological inhibition of both ALOX12 and ALOX15 decreased axonal degeneration compared with normal ALOX12/ALOX15...
...identifying CNS-penetrating, dual inhibitors of ALOX12 and ALOX15. TARGET/MARKER/PATHWAY: Arachidonate 12-lipoxygenase (ALOX12; 12-LOX); ALOX15 ( 15-LOX...
BioCentury | May 1, 2014
Distillery Therapeutics

Indication: Neurology

...Neurology Stroke Arachidonate 15-lipoxygenase (ALOX15; 15-LOX) In vitro and mouse studies suggest a new class of ALOX15...
...compound that inhibited ALOX15 with a nanomolar IC50 value. In a mouse neuron-based assay of Alox15-mediated...
BioCentury | Jan 28, 2013
Company News

Orexo, AstraZeneca deal

...and commercialize Orexo's OX-CLI and OX-ESI programs. The OX-ESI compounds inhibit arachidonate 15-lipoxygenase ( ALOX15 ; 15-LOX...
BioCentury | Jan 26, 2013
Company News

AstraZeneca gets option to preclinical Orexo program

...and commercialize Orexo's OX-CLI and OX-ESI programs. The OX-ESI compounds inhibit arachidonate 15-lipoxygenase ( ALOX15 ; 15-LOX...
BioCentury | Apr 26, 2012
Distillery Therapeutics

Indication: Autoimmune disease

...culture studies suggest increasing 15-LOX activity could help prevent autoimmune diseases. In cultured mouse cells, 15-lox...
...of systemic lupus erythematosus (SLE), mice lacking 15-lox had greater autoantibody production and glomerulonephritis than 15-lox-expressing...
BioCentury | Feb 6, 2012
Company News

Orexo, J&J deal

...of funding. The compounds, which inhibit leukotriene C4 synthase (LTC4S) and arachidonate 15-lipoxygenase ( ALOX15 ; 15-LOX...
BioCentury | May 12, 2011
Distillery Therapeutics

Indication: Cancer

...information Cancer Breast cancer Arachidonate 15-lipoxygenase (ALOX15; 15-LOX) Cell culture and mouse studies suggest that antagonizing ALOX15...
...preventing breast cancer metastasis. In a cell culture model of human breast cancer, inhibition of ALOX15...
...steps could include preclinical testing of ALOX15 inhibitors as adjuncts to cancer therapy. OX-ESI, an ALOX15...
BioCentury | Jun 7, 2010
Strategy

J&J's Pulmonary Push

...The OX-CLI and OX-ESI programs inhibit leukotriene C4 synthase (LTC4S) and arachidonate 15-lipoxygenase ( ALOX15 ; 15-LOX...
...on potential side effects as the safety will be evaluated in preclinical studies," Kenney said. ALOX15...
BioCentury | Jun 7, 2010
Company News

Orexo, J&J deal

...and OX-ESI. The compounds, which inhibit leukotriene C4 synthase (LTC4S) and arachidonate 15-lipoxygenase ( ALOX15 ; 15-LOX...
BioCentury | Jun 2, 2010
Company News

J&J units in pulmonary deals

...and OX-ESI. The compounds, which inhibit leukotriene C4 synthase (LTC4S) and arachidonate 15-lipoxygenase ( ALOX15 ; 15-LOX...
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