19:07 , Jan 4, 2019 |  BC Week In Review  |  Clinical News

Viela planning BLA submission for inebilizumab in rare CNS disorder

Viela Bio Inc. (Gaithersburg, Md.) said it will submit a BLA to FDA this half for inebilizumab (MEDI-551) to treat neuromyelitis optica spectrum disorder (NMOSD) after the compound met the primary endpoint in the Phase...
12:06 , Jan 3, 2019 |  BC Extra  |  Clinical News

Viela planning BLA submission for inebilizumab in rare CNS disorder

Viela Bio Inc. (Gaithersburg, Md.) said it will submit a BLA to FDA this half for inebilizumab (MEDI-551) to treat neuromyelitis optica spectrum disorder (NMOSD) after the compound met the primary endpoint in the Phase...
19:26 , Dec 21, 2018 |  BC Week In Review  |  Clinical News

Chugai's IL-6 receptor mAb meets in Phase III for rare CNS disorder

Chugai Pharmaceutical Co. Ltd. (Tokyo:4519) said satralizumab (SA237, RG6168) as monotherapy met the primary endpoint in the Phase III SAkuraStar trial to treat neuromyelitis optica spectrum disorder (NMOSD). The company plans to submit regulatory applications...
21:23 , Dec 19, 2018 |  BC Extra  |  Clinical News

Chugai's IL-6 receptor mAb meets in Phase III for rare CNS disorder

Chugai Pharmaceutical Co. Ltd. (Tokyo:4519) said satralizumab (SA237, RG6168) as monotherapy met the primary endpoint in the Phase III SAkuraStar trial to treat neuromyelitis optica spectrum disorder (NMOSD). The company plans to submit regulatory applications...
17:36 , Sep 28, 2018 |  BC Week In Review  |  Clinical News

Alexion eyes submissions for Soliris in rare CNS disease

Alexion Pharmaceuticals Inc. (NASDAQ:ALXN) plans to submit regulatory applications in the U.S., EU and Japan for Soliris eculizumab to treat relapsing neuromyelitis optica spectrum disorder (NMOSD) after the drug met the primary endpoint in the...
17:59 , Sep 24, 2018 |  BC Extra  |  Clinical News

Alexion eyes submissions for Soliris in rare CNS disease

Alexion Pharmaceuticals Inc. (NASDAQ:ALXN) plans to submit regulatory applications in the U.S., EU and Japan for Soliris eculizumab to treat relapsing neuromyelitis optica spectrum disorder (NMOSD) after the drug met the primary endpoint in the...
23:27 , Aug 17, 2017 |  BC Innovations  |  Targets & Mechanisms

GRP-THINK AT THE BBB

Biogen Inc. has discovered antibodies in patients with a rare CNS autoimmune disease that could provide a new way to deliver mAbs across the blood-brain barrier, an application with wide-reaching ramifications for neurologic drug development....
22:11 , Jul 3, 2017 |  BC Extra  |  Company News

Acer finds public path via Opexa merger

Rare disease company Acer Therapeutics Inc. (Cambridge, Mass.) will merge with gene therapy company Opexa Therapeutics Inc. (NASDAQ:OPXA) to form a publicly traded company that will retain Acer's name. The combined company intends to submit...
12:08 , May 24, 2017 |  BC Innovations  |  Distillery Therapeutics

Autoimmune disease

INDICATION: Autoimmune Cell culture studies suggest inhibiting FCGR could help treat neuromyelitis optica (NMO). In primary mouse astrocytes treated with serum from NMO patients, astrocyte knockout of FCGR decreased internalization of the NMO marker AQP4...
07:00 , Sep 18, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Neurology Aquaporin-4 (AQP4); corticotropin-releasing factor 1 (CRF1); corticotropin-releasing factor receptor 1 (CRHR1; CRFR1) Rat studies suggest inhibiting CRFR1 signaling could help prevent hypoxia-induced cerebral edema,...