19:41 , Jun 2, 2017 |  BioCentury  |  Product Development

Ears wide open

Based on unmet need alone, hearing loss should have been every bit as attractive to investors and drug developers as ophthalmic diseases, which entered a renaissance in the mid-2000s resulting in a multibillion-dollar market for...
07:00 , Apr 7, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Apoptotic peptidase activating factor 1 (APAF1); microRNA-21 (miR-21)

Cancer INDICATION: Ovarian cancer Patient sample, cell culture and mouse studies suggest promoting APAF1 expression could help treat ovarian cancer. In tissue samples from ovarian cancer patients, levels of miR-21 - which targets APAF1 - were higher...
07:00 , Aug 9, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Inflammation

Indication Target/marker/pathway Summary Licensing status Publication and contact information Inflammation Inflammation APAF1 interacting protein (APIP) In vitro and genetic sequencing studies suggest reducing APIP expression could help...
07:00 , Oct 30, 2008 |  BC Innovations  |  Cover Story

BCL-2 double take

Researchers at the Burnham Institute for Medical Research and the Dana-Farber Cancer Institute have independently identified peptides that modulate mitochondrial apoptosis and may have promise in cancer. The therapeutic strategies are, however, quite different: in...