BioCentury | Jun 2, 2017
Product Development

Ears wide open

...NRF2); PPAR = peroxisome proliferation activated receptor; KCNC1 = potassium channel Kv3.1; APAF1 = apoptotic peptidase activating factor 1 (APAF1...
BioCentury | Apr 7, 2016
Distillery Therapeutics

Therapeutics: Apoptotic peptidase activating factor 1 (APAF1); microRNA-21 (miR-21)

...Cancer INDICATION: Ovarian cancer Patient sample, cell culture and mouse studies suggest promoting APAF1 expression could...
...ovarian cancer. In tissue samples from ovarian cancer patients, levels of miR-21 - which targets APAF1...
...identifying and testing targeted therapies to inhibit miR-21 expression in ovarian cancer cells. TARGET/MARKER/PATHWAY: Apoptotic peptidase activating factor 1 (APAF1...
BioCentury | Aug 9, 2012
Distillery Therapeutics

Indication: Inflammation

...Indication Target/marker/pathway Summary Licensing status Publication and contact information Inflammation Inflammation APAF1 interacting protein (APIP) In...
BioCentury | Oct 30, 2008
Cover Story

BCL-2 double take

...membrane permeability. [ e ] Cytochrome C is released from the mitochondria and binds apoptotic peptidase activating factor 1 (APAF1...
BioCentury | Jul 30, 2007
Tools & Techniques

Caspase cascade

Caspase cascade By targeting procaspase-3 , BioLineRx Ltd. believes BL-4030 can bypass upstream elements in the intrinsic and extrinsic apoptosis pathways. In the intrinsic pathway, the mitochondrial membrane [1a] is depolarized due to cell stress, resulting...
BioCentury | Jul 14, 2003
Tools & Techniques

Fresh angle on apoptosis

A number of companies are attempting to manipulate the process of cell death at various points along the pathway that includes Bcl-2 and caspases . But Sunesis Pharmaceuticals Inc. is flying into uncharted territory with its...
BioCentury | Jun 16, 2003
Company News

Sunesis other research news

Researchers published in the Proceedings of the National Academy of Sciences the identification of compounds that activate the formation of the apoptosome complex, which is comprised of 6-7 monomers of the Apaf-1 protein. The compounds...
BioCentury | Sep 30, 2002
Company News

Idun, Vertex other research news

Researchers published in Nature that Bcl-2 overexpression increased lymphocyte numbers in mice and inhibited many apoptotic stimuli, but the absence of Apaf-1 or caspase-9 did not. The authors concluded that apoptosis initiated by Bcl-2 regulated...
BioCentury | Sep 10, 2001
Company News

Juntendo University School of Medicine other research news

Researchers published in the Proceedings of the National Academy of Sciences that treatment of mice with a dominant negative caspase recruitment domain of Apaf-1 decreased the apoptosis of nirgostriatal neurons induced by injecting mice with...
BioCentury | Jan 16, 2001
Company News

Cold Spring Harbor Laboratory other research news

Researchers published in Nature the reduction or loss of Apaf-1 mRNA expression in metastatic melanoma tumor biopsies and cell lines. They concluded that Apaf-1 may be a tumor suppressor, and that loss of Apaf-1 expression...
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