19:41 , Jun 2, 2017 |  BioCentury  |  Product Development

Ears wide open

Based on unmet need alone, hearing loss should have been every bit as attractive to investors and drug developers as ophthalmic diseases, which entered a renaissance in the mid-2000s resulting in a multibillion-dollar market for...
07:00 , Apr 7, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Apoptotic peptidase activating factor 1 (APAF1); microRNA-21 (miR-21)

Cancer INDICATION: Ovarian cancer Patient sample, cell culture and mouse studies suggest promoting APAF1 expression could help treat ovarian cancer. In tissue samples from ovarian cancer patients, levels of miR-21 - which targets APAF1 -...
07:00 , Aug 9, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Inflammation

Indication Target/marker/pathway Summary Licensing status Publication and contact information Inflammation Inflammation APAF1 interacting protein (APIP) In vitro and genetic sequencing studies suggest reducing APIP expression could help treat systemic inflammatory response syndrome (SIRS), which is...
07:00 , Oct 30, 2008 |  BC Innovations  |  Cover Story

BCL-2 double take

Researchers at the Burnham Institute for Medical Research and the Dana-Farber Cancer Institute have independently identified peptides that modulate mitochondrial apoptosis and may have promise in cancer. The therapeutic strategies are, however, quite different: in...