20:11 , Mar 1, 2019 |  BC Week In Review  |  Financial News

Blackstone, Novartis spin out cardiovascular newco Anthos

Leading its first deal since acquiring Clarus Ventures, Blackstone has partnered with Novartis AG (NYSE:NVS; SIX:NOVN) to launch Anthos Therapeutics Inc. (Cambridge, Mass.) with $250 million and Novartis antithrombotic MAA868. In exchange for the compound,...
02:43 , Feb 28, 2019 |  BC Week In Review  |  Company News

Akcea gains as Novartis exercises option for CV risk reduction therapy

Akcea Therapeutics Inc. (NASDAQ:AKCA) added $4.57 (17%) to $31.91 on Feb. 25 after Novartis AG (NYSE:NVS; SIX:NOVN) exercised an option to license its antisense APOA1 inhibitor in a renewed attempt at CV risk reduction. Novartis...
19:38 , Feb 27, 2019 |  BC Extra  |  Company News

Blackstone, Novartis spin out cardiovascular newco Anthos

Leading its first deal since acquiring Clarus Ventures, Blackstone has partnered with Novartis AG (NYSE:NVS; SIX:NOVN) to launch Anthos Therapeutics Inc. (Cambridge, Mass.) with $250 million and Novartis antithrombotic MAA868. In exchange for the compound,...
21:51 , Feb 25, 2019 |  BC Extra  |  Company News

Akcea gains as Novartis exercises option for CV risk reduction therapy

Akcea Therapeutics Inc. (NASDAQ:AKCA) added $4.57 (17%) to $31.91 on Monday after Novartis AG (NYSE:NVS; SIX:NOVN) exercised an option to license its antisense APOA1 inhibitor in a renewed attempt at CV risk reduction. Novartis is...
20:11 , Nov 26, 2018 |  BC Innovations  |  Distillery Therapeutics

Transplant

INDICATION: Heart transplant rejection Mouse studies suggest APOA/phospholipid-based nanoparticles loaded with rapamycin or a TRAF6 inhibitor could help prevent heart transplant rejection. The nanoparticles consist of APOA and natural phospholipid components of HDL cholesterol isolated...
18:09 , Oct 12, 2018 |  BC Week In Review  |  Clinical News

Akcea's AKCEA-APO(a)-LRx reduces LPA levels in Phase II

Akcea Therapeutics Inc. (NASDAQ:AKCA) said AKCEA-APO(a)-LRx led to significant dose-dependent reductions in lipoprotein(a) (LPA) compared with placebo in a Phase II trial to reduce elevated LPA levels in patients with established cardiovascular disease. The company...
01:14 , Oct 6, 2018 |  BioCentury  |  Finance

Large cap comeback

The biotech sector continued to be a stock pickers’ market through 3Q18 as there was a near even split between global biotech stocks that gained and lost value in the quarter. While 1H18 saw investors...
23:28 , Jun 7, 2018 |  BC Innovations  |  Translation in Brief

New Therapeutic Targets and Biomarkers: May 2018

New Therapeutic Targets and Biomarkers: May 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during May 2018. Therapeutic targets are defined as any protein, gene or other...
22:43 , Jun 5, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Pain Mouse studies suggest AIBP could help treat neuropathic pain. In mouse models of lipopolysaccharide (LPS)- and chemical-induced neuropathic pain, intrathecal AIBP decreased mechanical allodynia compared with vehicle. Also in the model of chemical-induced...
23:02 , May 31, 2018 |  BC Extra  |  Preclinical News

TLR4 inhibitor could help treat chemotherapy-induced pain

A Cell Reports study from researchers at University of California San Diego showed spinal injection of a toll-like receptor 4-binding protein reversed chemotherapy-induced neuropathic pain in mice. The findings suggest a new, non-opioid approach to...