03:45 , Apr 13, 2018 |  BC Innovations  |  Targets & Mechanisms

Meeting the burden

A major theme at this year’s AACR is the abundance of preclinical discovery driven by molecular signatures in patient samples, suggesting the research community is heeding the call for studies better grounded in human data,...
07:00 , Oct 17, 2016 |  BioCentury  |  Product Development

Yes we PanCAN

A major goal of a new multidrug platform study organized by the Pancreatic Cancer Action Network is to meet patients' needs better than traditional trials do. Among other things, that means accepting patients who have...
07:00 , Apr 19, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer APEX nuclease multifunctional DNA repair enzyme 1 (APEX1) In vitro studies identified APEX1 inhibitors that could help prevent resistance to chemotherapeutics. In vitro, a...
08:00 , Jan 27, 2003 |  BC Week In Review  |  Company News

Pacific Northwest Research Institute other research news

Researchers published in the Proceedings of the National Academy of Sciences the identification of PNRI-299. The compound selectively inhibits AP-1 dependent transcription by inhibiting REF-1, which reduces the reactive oxygen species that cause increased AP-1...