BC Week In Review | Apr 15, 2013
Company News

The Johns Hopkins Oncology Center other research news

Johns Hopkins researchers in the Howard Hughes Medical Institute and colleagues published in Nature Genetics the identification of a mutation in the APC gene (previously implicated in familial adenomatous polyposis) that is associated with increased...
BC Innovations | Jan 29, 2009
Targets & Mechanisms

Tales from the crypt

Separate studies by Dutch and U.S. researchers have identified a subset of cells that drive tumor growth in colon cancer. 1,2 These cancer stem cells could potentially be targeted to wipe out colorectal tumors at...
BioCentury | Apr 21, 2008
Emerging Company Profile

Cequent: Trojan bugs for RNAi

Even though investors and pharma companies have poured large sums of money into RNAi technologies, identifying a reliable method of delivering siRNA into cells remains an obstacle in many tissues and disease areas. Cequent Pharmaceuticals...
BC Week In Review | Jan 3, 2005
Clinical News

PreGen-Plus diagnostic data

Data from a trial in 2,507 evaluable patients showed that PreGen-Plus stool based DNA test was more sensitive than the fecal occult blood test (Hemoccult II) for the detection of colorectal cancer. The DNA panel...
BC Week In Review | Jan 20, 2003
Company News

AmberGen other research news

Researchers published in Nature Biotechnology the use of HTS-PTT to screen for truncated APC proteins, which frequently result from mutations in the APC gene . The test uses an ELISA format amenable to use in 96-well...
BC Week In Review | Jul 22, 2002
Company News

Memory Pharmaceuticals other research news

Researchers published in the Proceedings of the National Academy of Sciences evidence that Fen1 is involved in tumorigenesis. Homozygous deletion of Fen1 in mice resulted in embryonic lethality, however Fen1 heterozygous deleted mice showed a...
BC Week In Review | May 20, 2002
Company News

Myriad Genetics sales and marketing update

MYGN launched Colaris AP predictive medicine product to determine a patient's risk of hereditary colon cancer. The product detects mutations in the APC gene , which cause familial adenomatous polyposis (FAP) and attenuated FAP, both of...
BC Week In Review | Feb 4, 2002
Clinical News

DNA-based stool test: Pilot

EXAS reported in The New England Journal of Medicine that in a U.S. feasibility study of its fecal DNA test in 74 volunteers or patients with adenomas or colorectal cancer, APC gene mutations were identified...
BC Week In Review | Aug 7, 2000
Company News

Genzyme Molecular, Virco Group, City of Hope Cancer Center, Laboratory Corp. of America Holdings deal

GZMO granted non-exclusive licenses for the APC gene to LH and for the MSH/2 gene to LH and the Center for use in colon cancer diagnostics. GZMO also granted a non-exclusive license to Virco subsidiary...
BC Week In Review | Jun 1, 1998
Clinical News

Aphton preclinical data

APHT researchers demonstrated that treatment with Gastrimmune to stimulate an immune response against the gastrin-17 growth factor increased survival of mice carrying a mutation in the APC gene , which causes familial adenomatous polyposis coli , a...
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