BioCentury | Feb 5, 2020
Product Development

2019-nCoV drug discovery: HHS funds Regeneron mAbs and BenevolentAI deploys machine learning

...is thought to enter cells through ACE2 binding, which triggers endocytosis, a process promoted by AAK1...
...to 2019-nCoV identified six compounds previously tested in the clinic that were predicted to bind AAK1...
...The 2019n-CoV content is free to all who visit the site. Targets AAK1 - AP2 associated kinase 1...
BioCentury | Oct 17, 2017
Distillery Therapeutics

Infectious disease

INDICATION: Malaria Mosquito studies suggest genetically modifying the insects or feeding them genetically modified bacteria could help prevent transmission of malaria. In Anopheles stephensi mosquitoes fed a Plasmodium falciparum -infected blood meal, midgut overexpression of...
BioCentury | Jul 18, 2017
Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer Patient sample, in vitro , cell culture and mouse studies identified a benzamide-based CSNK1A activator that could help treat Wnt signaling-driven colorectal cancer. In colorectal cancer patients, low tumor levels of CSNK1A were...
BioCentury | May 16, 2017
Distillery Therapeutics

Cancer

INDICATION: Breast cancer Cell culture and mouse studies suggest inhibiting GPNMB or its regulator MAFK could help treat breast cancer. Human triple-negative breast cancer (TNBC) cell lines expressed higher levels of MAFK than luminal- or...
BioCentury | Mar 21, 2017
Distillery Therapeutics

Cancer

INDICATION: Cancer; colorectal cancer; melanoma Mouse studies suggest an engineered Salmonella strain that agonizes TLR4 and TLR5 could help treat melanoma, colorectal and other cancers. An attenuated strain of S. typhimurium was engineered to express...
BioCentury | Aug 4, 2016
Distillery Therapeutics

Therapeutics: AP2 associated kinase 1 (AAK1)

...or spinal nerve ligation-induced neuropathic pain, AAK1 knockout decreased measures of pain compared with normal AAK1...
...of pain compared with normal AAK1 expression. In both models with normal AAK1 expression, an AAK1...
...Next steps by Bristol-Myers Squibb Co. could include identifying and testing other AAK1 inhibitors. TARGET/MARKER/PATHWAY: AP2 associated kinase 1 (AAK1)...
BioCentury | Jun 3, 2013
Finance

Seeds to trees

Flush with cash from its existing holdings and not seeing enough worthwhile venture deals to spend it on, Novo A/S has decided to expand its growth equity investments in mature companies. After a proof-of-principle deal...
BioCentury | Oct 30, 2008
Tools & Techniques

Expanding the kinase kingdom

...results of the loss-of-function screen identified several kinases, including CDK6 , ERBB3 , FYN , AAK1...
Items per page:
1 - 8 of 8