BioCentury | Jul 11, 2018
Translation in Brief

Poisoning the stromal chalice

A study published in the Journal of Clinical Investigation suggests antibody-drug conjugates targeting the tumor stroma could treat cancers by co-opting a stromal mechanism to feed cytotoxic drugs to the surrounding tumor cells. Tumor-associated stroma,...
BioCentury | Jun 13, 2018
Distillery Therapeutics

Cancer

INDICATION: Solid tumors; pancreatic cancer; colorectal cancer; breast cancer; lung cancer; ovarian cancer Patient sample and mouse studies suggest anti-ANTXR1 antibody-drug conjugates (ADCs) could help treat solid tumors. In tissue samples from esophageal, kidney, uterine,...
BioCentury | May 2, 2018
Distillery Techniques

Biomarkers

...kinase kinase kinase 1 (MAP3K1; MEKK1), phosphatidic acid phosphatase type 2A (PPAP2A; LPP1; PAP2), anthrax toxin receptor 2 (ANTXR2...
...transcript 1 (NEAT1). In 89 of the patients, genomic analysis identified associations between mutations in ANTXR2...
BioCentury | Dec 5, 2017
Distillery Therapeutics

Cancer

INDICATION: Breast cancer Patient sample, cell culture and mouse studies suggest chimeric antigen receptor (CAR) T cells targeting ANTXR1 could help treat triple-negative breast cancer (TNBC). In patient samples, levels of ANTXR1 were higher in...
BioCentury | Jun 20, 2017
Distillery Therapeutics

Other

...studies suggest inhibiting COL6A1 could help treat hyaline fibromatosis syndrome (HFS), which is caused by ANTXR2...
...Next steps could include identifying and testing inhibitors of COL6A1 in the model. TARGET/MARKER/PATHWAY: Anthrax toxin receptor 2 (ANTXR2...
...of Technology Lausanne (EPFL), Lausanne, Switzerland email: gisou.vandergoot@epfl.ch Hongjiang Li Swiss Federal Institute of Technology Lausanne (EPFL) Anthrax toxin receptor 2 (ANTXR2) Collagen...
BioCentury | Mar 8, 2012
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Anthrax toxin receptor 1 (ANTXR1; TEM8) Studies in mice suggest inhibiting TEM8 could help treat cancer. In multiple mouse models of cancer, injection of...
BioCentury | Mar 8, 2012
Distillery Therapeutics

Indication: Autoimmune Disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Autoimmune disease Autoimmune disease Indoleamine 2, 3-dioxygenase (INDO; IDO) Mouse studies suggest IDO could help treat and prevent autoimmune diseases. In lupus-prone mice, an IDO inhibitor...
BioCentury | Mar 8, 2012
Targets & Mechanisms

A TEM to kill

...protective antigen inhibits tumor angiogenesis, and the group is continuing to study how ANTXR1 and ANTXR2...
BioCentury | Oct 13, 2007
Clinical News

Dual-action anthrax antitoxin and vaccine

...VLPs) were engineered for multivalent display of both the high-affinity anthrax toxin-binding domain of the ANTXR2...
BioCentury | Oct 29, 2001
Company News

University of Wisconsin other research news

Researchers published in Nature the cloning of a human cellular receptor (ATR) for protective antigen (PA), one component of the anthrax toxin. They reported that the receptor has an extracellular von Willebrand factor A domain...
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