BioCentury | Nov 12, 2015
Distillery Therapeutics

Therapeutics: Anaphase promoting complex (ANAPC)

Cancer Cell culture studies suggest partially inhibiting ANAPC could help treat cohesion-defective cancers. In multiple human cancer cell lines, ANAPC knockdown induced more death in cells with cohesion defects than in cells with normal cohesion....
BioCentury | Oct 28, 2010
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Anaphase promoting complex (ANAPC) An in vitro study suggests that a small molecule that inhibits the ANAPC to induce mitotic arrest could help treat...
BioCentury | Jun 11, 2009
Targets & Mechanisms

K-Ras' Achilles' heel

...1 ( PLK1 ; STPK13 ), anaphase promoting complex subunit 1 ( ANAPC1 ) and ANAPC4...
BioCentury | Jun 11, 2009
Distillery Therapeutics

Indication: Cancer

...ANAPC1); ANAPC4 A study in cell culture and in mice suggests that antagonizing PLK1, ANAPC1, ANAPC4...
...tumors. A genomewide RNAi screen showed that small hairpin RNA knockdown of PLK1, ANAPC1 and ANAPC4...
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