BioCentury | Apr 4, 2019
Preclinical News

Nimbus exposes complete ACLY structure, discovers allosteric inhibitory sites

...ACLY inhibitor in development. Keiper said that bempedoic acid weakly inhibits ACLY and also activates AMPK...
...safety. Esperion did not respond to inquiries. Targets: ACLY - ATP citrate lyase; AMPK - AMP-activated protein kinase Sandi...
BioCentury | Feb 20, 2019
Distillery Therapeutics

Hepatic

...disease Mouse studies suggest INSIG1 could help treat non-alcoholic fatty liver disease (NAFLD). In a AMPK-knockout...
...could include testing INSIG1 in other NAFLD models. TARGET/MARKER/PATHWAY: Insulin induced gene 1 (INSIG1); AMP-activated protein kinase (AMPK...
...CONTACT: Yu Li, Chinese Academy of Sciences, Shanghai, China email: liyu@sibs.ac.cn Claire Quang Chinese Academy of Sciences AMP-activated protein kinase (AMPK) Insulin...
BioCentury | Oct 25, 2018
Distillery Techniques

Assays and screens

...genes. In a proof-of-concept experiment, the screen predicted calcium channel blockers would also activate AMP-activated protein kinase (AMPK...
...levels of bilirubin and higher levels of alkaline phosphatase activity in blood -- markers of AMPK...
...Jing-Dong Jackie Han, Chinese Academy of Sciences, Shanghai, China email: jdhan@picb.ac.cn Alicia Parker Chinese Academy of Sciences AMP-activated protein kinase (AMPK) Calcium...
BioCentury | Oct 11, 2018
Distillery Therapeutics

Hepatic

...Huang, East Carolina University, Greenville, N.C. email: huangh@ecu.edu Meghan Sullivan Beth Israel Deaconess Medical Center East Carolina University AMP-activated protein kinase (AMPK) Rho-associated...
BioCentury | Aug 10, 2018
Targets & Mechanisms

Getting to function

...which helps build muscle mass . AMPK-PGC-1α increases mitochondrial biogenesis and respiratory capacity. Separately, AMPK...
...Activin receptor type 2B; AKT (AKT1; PKB; PKBA) - Protein kinase B; AMPK - AMP-activated protein kinase...
...PKB; PKBA) - Protein kinase B Apelin (APLN) APLNR (APJ) - Apelin receptor AMPK - AMP-activated protein kinase Allison...
BioCentury | Aug 1, 2018
Distillery Therapeutics

Pulmonary

...mediator transforming growth factor β 1 (TGFB1), a tool compound AMPK activator or the generic AMPK...
...AMPK activator, in Phase I testing for Type II diabetes and non-alcoholic steatohepatitis (NASH). TARGET/MARKER/PATHWAY: AMP-activated protein kinase...
...activator, in Phase I testing for Type II diabetes and non-alcoholic steatohepatitis (NASH). TARGET/MARKER/PATHWAY: AMP-activated protein kinase (AMPK...
BioCentury | Jun 20, 2018
Distillery Therapeutics

Cancer

...targeting AMPK or knockout of AMPK decreased viability compared with a non-targeting shRNA or normal AMPK...
...steps could include identifying and testing AMPK inhibitors in animal models of glioblastoma. TARGET/MARKER/PATHWAY: AMP-activated protein kinase (AMPK...
...Dasgupta, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio email: Biplab.dasgupta@cchmc.org Jennie Walters Cincinnati Children's Hospital Medical Center AMP-activated protein kinase (AMPK...
BioCentury | Jun 14, 2018
Translation in Brief

There’s more to MIF

...for diagnosing or treating MIF-2-associated diseases. Miller, E., et. al. “Macrophage migration inhibitory factor stimulates AMP-activated protein kinase...
BioCentury | Oct 5, 2017
Translation in Brief

AMPK addendum

...A Science paper form Merck & Co. Inc. (NYSE:MRK) suggests that while AMP-activated protein kinase (AMPK) agonists can...
...The AMPK pathway is a primary regulator of energy level responses in cells, with activated AMPK...
...but induces cardiac hypertrophy." Science (2017) Michael Leviten, Senior Writer AMPK activators Merck & Co. Inc. Pfizer Inc. Poxel S.A. AMP-activated protein kinase (AMPK...
BioCentury | Apr 11, 2017
Distillery Therapeutics

Hepatic

...steps could include testing AMPK activators in other models of NAFLD. Betagenon AB has the AMPK...
...mangeferin and barberine that activates AMPK, in preclinical testing for non-alcoholic steatohepatitis (NASH). TARGET/MARKER/PATHWAY: AMP-activated protein kinase (AMPK...
...U.K. email: david.carling@lms.mrc.ac.uk CONTACT: Angela Woods, same affiliation as above email: angela.woods@lms.mrc.ac.uk Alicia Parker Medical Research Council AMP-activated protein kinase (AMPK) Liver...
Items per page:
1 - 10 of 108