DISEASE CATEGORY: Cancer INDICATION: Skin cancer A Yale University team showed that bioadhesive nanoparticle delivery of topoisomerase inhibitor camptothecin could treat squamous cell carcinoma. The nanoparticle therapy was created by incubating non-adhesive hyperbranched polyglycerol-based nanoparticles...

DISEASE CATEGORY: Cancer INDICATION: Acute lymphoblastic leukemia (ALL) Inhibiting PON2, a lactonase, could treat B cell ALL (B-ALL). Levels of PON2 mRNA were higher in Philadelphia chromosome-positive B-ALL cells from patients than in normal pre-B cells,...

DISEASE CATEGORY: Cancer INDICATION: Ovarian cancer; melanoma; colorectal cancer CAR T cells targeting folate receptor FOLR2 could treat ovarian cancer, melanoma and colorectal cancer. Among patients with stage III or IV ovarian cancer, high FOLR2...

DISEASE CATEGORY: Endocrine/metabolic INDICATION: Obesity; liver disease Reducing levels of eIF4E or lowering the RNA cap-binding protein’s activity by blocking its phosphorylation could treat obesity...

DISEASE CATEGORY: Cancer INDICATION: Acute lymphoblastic leukemia (ALL) A CDK12-targeted degrader, designed by a Dana-Farber Cancer Institute and Harvard Medical School team co-led by Nathanael Gray, could treat T cell ALL. The degrader’s targeting moiety was derived...

DISEASE CATEGORY: Cancer INDICATION: Liver cancer An oxopropylaminoacetic acid-based CXCR4 antagonist could treat hepatocellular carcinoma (HCC). The CXCR4 inhibitor, optimized from a compound the...

DISEASE CATEGORY: Cancer INDICATION: Ovarian cancer A YBX1 inhibitor derived from azopodophyllotoxin could treat ovarian cancer. In a panel of five human ovarian cancer cell lines, the compound inhibited growth with IC50 values of 1.27-6.8...

DISEASE CATEGORY: Neurology INDICATION: Alzheimer’s disease Blocking RECK, a membrane-tethered inhibitor of APP-cleaving enzyme ADAM10, could treat Alzheimer’s disease. Levels of membrane-tethered...

DISEASE CATEGORY: Infectious disease INDICATION: Urinary tract infection (UTI); Escherichia A vaccine containing uropathogenic E. coli antigens and an adjuvant that promotes Th1 immune responses could prevent UTIs. Mice immunized via intrabladder delivery of a lysate...

DISEASE CATEGORY: Infectious disease INDICATION: Viral hemorrhagic fever A mAb targeting Junin virus glycoprotein could treat infections by Junin virus, which causes Argentine hemorrhagic fever. In monkey kidney epithelial cells, a humanized mAb against Junin virus...