BioCentury | Mar 17, 2020
Product Development

Eureka tackles major challenges for T cells in solid tumors with $45M E round, Lyell deal

...enables the T cells to infiltrate efficiently into solid tumors.” The T cell therapy targeting AFP...
...Undisclosed new and existing investors participated in Eureka’s series E round. Targets APF - Alpha fetoprotein...
...Forkhead box P3 TCR - T cell receptor Lauren Martz, Senior Editor Eureka Therapeutics Inc. Lyell Immunopharma Inc. Alpha fetoprotein (AFP...
BioCentury | Jan 13, 2020
Clinical News

Adaptimmune rises on early promise for SPEAR TCR cell therapies in solid tumors

...autologous T cell therapies genetically modified to express TCRs against a given target. ADP-A2AFP targets AFP...
...and ADP-A2M4CD8 also targets MAGEA4, but also expresses the CD8α co-receptor. Targets - AFP - Alpha fetoprotein...
BioCentury | Aug 22, 2019
Emerging Company Profile

Tscan: Tracking down novel T cell targets

...TCR therapies include Adaptimmune, which has three programs against known TCR targets MAGEA10, MAGEA4 and AFP...
...U.K. Neon Therapeutics Inc. (NASDAQ:NTGN), Cambridge, Mass. Tscan Therapeutics Inc., Boston, Mass. Targets AFP - Alpha fetoprotein...
BioCentury | May 13, 2019
Company News

May 13 Company Quick Takes: PeptiDream/JCR, Grail, Lilly, Onconova/HanX, Regeneron

...treatment of hepatocellular carcinoma patients previously treated with Nexavar sorafenib and who have α fetoprotein (AFP...
...increased risk of gastrointestinal hemorrhage (see "Cyramza Leads to Median OS of 8.5 Months in AFP-High...
BioCentury | Mar 29, 2019
Targets & Mechanisms

Next-wave targets at AACR 2019 start filling the blanks in the tumor microenvironment

...cancer, uterine cancer Dog, mouse Tumor KLF5 expression could help predict efficacy of treatment with alpha fetoprotein...
BioCentury | Feb 1, 2019
Clinical News

Cyramza leads to median OS of 8.5 months in AFP-high HCC population

...Phase III REACH-2 trial to treat hepatocellular carcinoma (HCC) in patients with high α fetoprotein (AFP...
...the U.S., EU and Japan. The double-blind, international trial enrolled 292 patients with high baseline AFP...
...III data Milestone: NA Brian Moy Cyramza, ramucirumab (IMC-1121B, LY3009806) American Society of Clinical Oncology Eli Lilly and Co. Alpha fetoprotein (AFP) Vascular...
BioCentury | Dec 21, 2018
Product R&D

Cell therapies seek solid ground

...NASDAQ:BLUE) HPV-16 E6 TCR Cervical cancer Ph I/II α fetoprotein (AFP) Adaptimmune Therapeutics plc (NASDAQ:ADAP) AFP...
...Adaptimmune is focused on antigens found exclusively on tumors, such as cancer testis antigens and AFP...
...School of Medicine, Philadelphia, Pa. University of Texas MD Anderson Cancer Center, Houston, Texas Targets AFP...
BioCentury | Sep 21, 2018
Clinical News

Eureka's ET140202 leads to tumor regression in Phase I for HCC

...tumor regression and two cases of partial tumor regression in six evaluable patients with alpha fetoprotein (AFP)-positive...
...alpha fetoprotein (AFP) Description: TCR-mimicking antibody targeting an AFP-peptide/HLA-A2 complex using the ARTEMIS platform Indication: Treat AFP-positive...
...AFP expression Status: Preliminary Phase I data Milestone: Start Phase I (2019) Jaime De Leon Eureka Therapeutics Inc. Alpha fetoprotein...
BioCentury | Jun 7, 2018
Clinical News

Exact HCC assay significantly better than SOC

...and specificity in identifying HCC, especially early stage cancer, vs. the standard of care alpha fetoprotein (AFP...
...case-control study, Exact's test was significantly better at discriminating HCC from cirrhotic controls vs. the AFP...
...Kisiel, assistant professor of medicine at the Mayo Clinic, told BioCentury that the sensitivity of AFP...
BioCentury | Jun 6, 2018
Product Development

Second (Ex)act

...Exact’s blood test was significantly better at discriminating HCC from cirrhotic controls vs. the alpha fetoprotein (AFP...
...therapy. Standard of care for HCC surveillance is ultrasound imaging combined with serum measurements of AFP...
...twice as long as cirrhotic patients without HCC surveillance. But sensitivity of ultrasound and AFP...
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