BioCentury | Feb 20, 2020
Finance

With $88M series B, Spruce seeks short path to approval in rare endocrine disorder

...proceed quickly into Phase IIa trials. A 12-week study showed reductions in key disease biomarkers ACTH...
...was announced at $20 million in October 2017 (see “Sprucely Debut” ). Targets ACTH - adrenocorticotropic hormone...
BioCentury | Aug 23, 2018
Distillery Therapeutics

Endocrine/metabolic

...inhibitor Zelboraf vemurafenib could help treat Cushing disease, which involves excessive cortisol production triggered by ACTH-secreting...
...BRAF V600E mutation. In two human corticotroph adenoma cell lines expressing the mutation, Zelboraf decreased ACTH...
...mutation-positive Erdheim-Chester disease and in Phase II testing for BRAF mutation-positive thyroid cancer. TARGET/MARKER/PATHWAY: BRAF; adrenocorticotropic hormone (ACTH)...
BioCentury | Mar 16, 2017
Targets & Mechanisms

Bone appétit!

...is activated by at least four other ligands - α-MSH , β-MSH , γ-MSH and ACTH...
...& Co. Ltd. (Tokyo:4507), Osaka, Japan University of Michigan, Ann Arbor, Mich. Targets ACTH - Adrenocorticotropic hormone...
BioCentury | Nov 15, 2016
Clinical News

H.P. Acthar Gel: Ph IV started

...U.K. Product: H.P. Acthar Gel repository corticotropin injection Business: Autoimmune Molecular target: Corticoid receptors Description: Adrenocorticotropic hormone...
BioCentury | Mar 3, 2016
Distillery Therapeutics

Therapeutics: Corticotropin-releasing factor receptor 1 (CRHR1; CRFR1)

...vehicle. In a mouse model of stress, pretreatment with the compound decreased blood levels of adrenocorticotropic hormone...
BioCentury | Jul 14, 2014
Company News

Novartis, Questcor deal

...is a long-chain polypeptide comprised of the first 24 amino acids of the adrenocorticotrophic hormone (ACTH...
BioCentury | Feb 27, 2014
Distillery Techniques

Technology: Drug platforms

...mice, STAP cells gave rise to all three germ layers and germ cells. In culture, adrenocorticotropic hormone (Acth)...
BioCentury | Feb 27, 2014
Tools & Techniques

(Pluri)potent acid

...a remedy, Vacanti's team added adrenocorticotropic hormone (ACTH) and leukemia inhibitory factor (LIF) to STAP cell cultures. ACTH...
...describing how STAP cells cultured in medium containing fibroblast growth factor 4 (FGF4) instead of ACTH...
BioCentury | Feb 17, 2014
Clinical News

Signifor LAR pasireotide regulatory update

...of cortisol in the blood. In Cushing's disease, excess cortisol production is triggered by an adrenocorticotropic hormone (ACTH)-secreting...
BioCentury | Jan 13, 2014
Finance

Buyside View XXII: 'Grown up' means growth

...discounted to any of its peers," Lynch said. The company markets H.P. Acthar , an adrenocorticotropic hormone...
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