BioCentury | Oct 30, 2019
Company News

Amgen narrows neuro focus to inflammation

Despite early success for Amgen’s first marketed neurology product, the company will exit research and early development for neuroscience, narrowing its focus to neuroinflammation. “To compete effectively, we need to make investments in the areas...
BioCentury | Sep 16, 2019
Company News

Lundbeck enters migraine race with $2B takeout of Alder

...Compound, Discovery Hub" ). Alder's other development program is ALD1910, a potential first-in-class mAb targeting ADCYAP1...
...DKK235.90 in afternoon trading, while Alder climbed $8.34 (82%) to $18.40. Targets: ADCYAP1 (PACAP) - Adenylate cyclase activating polypeptide pituitary...
BioCentury | May 28, 2019
Company News

Months after scuttling IPO bid, Centrexion adds to balance sheet with Lilly deal for pain therapy

A licensing deal with Lilly for an analgesic will bolster Centrexion's balance sheet six months after it canceled plans for an IPO. Centrexion will receive $47.5 million up front and is eligible for $950 million...
BioCentury | Apr 1, 2019
Company News

Salix licenses new NASH target from UCLA

...comprises maxadilan, a vasodilator peptide found in sand fly saliva that binds ADCYAP1R1, fused to ADCYAP1...
...Salix is a subsidiary of Bausch Health Companies Inc. (TSX:BHC; NYSE:BHC). Targets: ADCYAP1 (PACAP) - Adenylate cyclase activating polypeptide pituitary...
...of California Los Angeles Adenylate cyclase activating polypeptide 1 pituitary receptor type I (ADCYAP1R1) (PAC1) Adenylate cyclase activating polypeptide pituitary (ADCYAP1) (PACAP) Non-alcoholic...
BioCentury | Jan 23, 2019
Distillery Therapeutics

Neurology

...Migraine In vitro and rat studies identified a mAb against the ADCYAP1-derived peptides PACAP-38 and PACAP-27...
...both PACAP-38 and PACAP-27, followed by humanization of the top hit, yielded ALD1910, which bound PACAP-38...
...and PACAP-27, followed by humanization of the top hit, yielded ALD1910, which bound PACAP-38 and PACAP-27...
BioCentury | Jan 25, 2017
Distillery Therapeutics

Neurology

...INDICATION: Spinal muscular atrophy (SMA) Cell culture and mouse studies suggest a modified ADCYAP1 -derived peptide...
...steps could include testing the modified peptide in additional models of SBMA. TARGET/MARKER/PATHWAY: Adenylate cyclase activating polypeptide pituitary (ADCYAP1; PACAP...
...doi:10.1126/scitranslmed.aaf9526 CONTACT: Maria Pennuto, University of Trento, Trento, Italy email: mpennuto@dti.telethon.it Hongjiang Li University of Trento Adenylate cyclase activating polypeptide pituitary (ADCYAP1) (PACAP) Androgen...
BioCentury | Sep 14, 2015
Strategy

Mind melding

Novartis AG's third neuroscience deal of the summer checks two boxes for the pharma by sharing the risk for a BACE inhibitor program and adding another late-stage program in neurology, all without increasing the pharma's...
BioCentury | Mar 11, 2013
Clinical News

Cu-64-TP3805 diagnostic data

...Business: Diagnostic Molecular target: Vasoactive intestinal peptide receptor 1 (VPAC1) Description: Adenylate cyclase activating polypeptide pituitary ( ADCYAP1 ; PACAP...
BioCentury | Mar 17, 2011
Targets & Mechanisms

The hormone trigger in PTSD

...with depression. PTSD typically is treated with talk therapy and anxiolytics. Adenylate cyclase activating polypeptide pituitary ( ADCYAP1 ; PACAP...
...no correlation between PACAP levels and PTSD symptoms in men. The reason for the female-specific PACAP-PAC1...
...said. "They probably all work together," the PACAP system included. Because the effect of inhibiting PACAP...
BioCentury | Mar 10, 2011
Distillery Therapeutics

Indication: Neurology

...pathway Summary Licensing status Publication and contact information Neurology Post-traumatic stress disorder (PTSD) Adenylate cyclase activating polypeptide pituitary (ADCYAP1; PACAP...
...pituitary receptor type I (ADCYAP1R1; PAC1) Studies in humans and in rodents suggest that antagonizing PACAP...
...of Pacap in the amygdala compared with vehicle control. In traumatized women, blood levels of PACAP...
Items per page:
1 - 10 of 18