BC Innovations | Mar 14, 2017
Distillery Therapeutics

Neurology

INDICATION: Pain Cell culture and mouse studies identified a chlorochromenone-based ADCY1 inhibitor that could help treat pain. Screening and testing in HEK cell-based activity assays of commercially available natural products identified a chlorochromenone analog that...
BC Week In Review | Feb 23, 2015
Company News

Genticel S.A, Serum Institute of India deal

Genticel granted the institute exclusive rights to Vaxiclase technology in acellular multivalent combination vaccines to prevent Bordetella pertussis (whooping cough). The license covers all countries except the U.S., Australia, Canada, Israel, Japan, New Zealand, Turkey...
BC Innovations | Jan 9, 2014
Distillery Therapeutics

Indication: Ophthalmic disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Ophthalmic disease Ophthalmic disease Adrenergic receptor a1 (ADRA1); ADRA2; adenylate cyclase 1 (ADCY1; AC1) Mouse studies suggest antagonizing ADRA1 or stimulating ADRA2 could help treat Stargardt...
BC Innovations | Jun 13, 2013
Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Pain Adenylate cyclase 1 (ADCY1; AC1); NMDA receptor NR2B subtype (GRIN2B; NR2B) Mouse studies suggest inhibiting GRIN2B in the insular cortex...
BC Innovations | Feb 16, 2012
Targets & Mechanisms

Still un-sirtuin

Researchers at the NIH have proposed a new mechanism to explain the beneficial metabolic effects of resveratrol, a polyphenol compound from red wine thought by many to act primarily on sirtuin 1 . The NIH team...
BC Innovations | Feb 10, 2011
Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Pain Adenylate cyclase 1 (ADCY1; AC1) Studies in cell culture and in rodents suggest that a small molecule antagonist of AC1 could help treat neuropathic...
BC Innovations | Dec 16, 2010
Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Pain Adenylate cyclase 1 (ADCY1; AC1); protein kinase Mz (PKMz) Studies in mice suggest that inhibiting PKMz could help treat neuropathic...
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