BioCentury | May 7, 2019
Distillery Techniques

Expression of multigene panels in CNS cell types as markers of early AD

...microglia, potassium voltage-gated channel interacting protein 1 (KCNIP1) in OPCs and denosine deaminase RNA-specific B2 (ADARB2...
...Tsai, same affiliation as above email: lhtsai@mit.edu Sandi Wong Broad Institute of MIT and Harvard Massachusetts Institute of Technology Adenosine deaminase RNA-specific B2 (ADARB2) Complement...
BioCentury | Jan 4, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: December 2017

...Diabetes Arginine vasopressin receptor 2 (AVPR2) Cell culture studies suggest correcting AVPR2 mutations with a Cas13b/adenosine deaminase RNA-specific B2 (ADARB2)-based...
BioCentury | Dec 20, 2017
Distillery Techniques

Drug platforms

...TECHNOLOGY: Gene therapy An ADARB2-based method of editing RNA could help treat diseases caused by point...
...a gRNA-binding peptide -- CRISPR-associated protein 13b (Cas13b) or a bacteriophage peptide -- and an ADARB2...
...domain engineered for enhanced efficiency or N-terminally truncated for delivery via adeno-associated viral (AAV) vectors. ADARB2...
BioCentury | Nov 21, 2013
Distillery Therapeutics

Indication: Neurology

...RNA-binding proteins, including heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1), purine-rich element binding protein A (PURA) and adenosine deaminase RNA-specific B2 (ADARB2)...
BioCentury | Nov 7, 2013
Cover Story

ALS antisense oligonucleotides

...RNA foci. The foci colocalized with a different RNA-binding protein-adenosine deaminase RNA-specific B2 (ADARB2)-and the binding and sequestering of ADARB2...
...not in cells from healthy controls. In iPS cell-derived neurons from healthy controls, knockout of ADARB2...
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