18:57 , Sep 20, 2017 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Alzheimer’s disease (AD) In vitro and cell culture studies identified an analog of the antibiotic novobiocin that inhibits the AHA1-Hsp90 interaction and could help treat AD and other tauopathies. Chemical synthesis, in vitro binding assays...
13:36 , Sep 14, 2017 |  BC Innovations  |  Translation in Brief

New Therapeutic Targets and Biomarkers: August 2017

New Therapeutic Targets and Biomarkers: August 2017 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during August 2017. Therapeutic targets are defined as any protein, gene or other molecule...
00:17 , Aug 22, 2017 |  BC Extra  |  Preclinical News

AHA1 inhibition reduces tau accumulation

In a paper published in Proceedings of the National Academy of Sciences, researchers at the University of South Florida and University of Kansas showed that inhibition of activator of heat shock protein 90 (Hsp90) ATPase...