19:28 , Jan 17, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Huntington's disease (HD) Cell culture studies suggest promoting the expression of ATF4 and CTH could help treat HD. In a mouse striatal cell line expressing mutant HTT and cultured under HD-associated low cysteine conditions, a...
18:24 , Jun 22, 2017 |  BC Innovations  |  Translation in Brief

TERS talk

A UCSD group has added "transmissible ER stress (TERS)" to the list of cancer's survival strategies. In a study published this month in Science Signaling, the group showed cancer cells undergoing ER stress send soluble...
07:00 , Jul 21, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Glutamic-pyruvic transaminase 2 (GPT2); activating transcription factor 4 (ATF4); phosphoinositide 3-kinase catalytic subunit α polypeptide (PI3KC

Cancer INDICATION: Colorectal cancer Patient sample, cell culture and mouse studies suggest inhibiting GPT2 or ATF4 could help treat PI3KCA-mutant colorectal cancer. In tumor samples from colorectal cancer patients, GPT2 expression was higher in tumors expressing mutant...
07:00 , Jun 18, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Activating transcription factor 4 (ATF4); heme oxygenase decycling 1 (HMOX1; HO-1; Hsp32)

Cancer INDICATION: Cancer Cell culture, mouse and patient sample studies suggest inhibiting ATF4 could help treat cancer. In patients with breast or sarcomal tumors, levels of ATF4 and the antioxidant protein HMOX1 were higher in metastatic tumors...
08:00 , Jan 10, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Musculoskeletal disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Musculoskeletal disease Osteoporosis MicroRNA-214 (miR-214) In vitro and mouse studies suggest inhibiting miR-214...