BioCentury | Oct 19, 2020
Finance

How Nimbus’ focus on internal pipeline could point to long-awaited exit

...With that deal, Gilead obtained a portfolio of ACAC...
...the pharma’s own program fails.TARGETSACAC (ACC) – Acetyl-Coenzyme A carboxylase AMPK...
BioCentury | May 6, 2020
Product Development

Phase II data show Novo’s semaglutide leads the pack on NASH resolution

...regarding its effect on fibrosis. Semaglutide is also in a Phase II combination trial with ACAC...
...modulators comprising amino acids and derivatives designed to improve liver health. Targets ACAC (ACC) - Acetyl-coenzyme A carboxylase...
BioCentury | Dec 17, 2019
Company News

Dec. 16 Company Quick Takes: Greenlight for Roche-Spark deal; plus BMS, Gilead, BioMarin, FDA guidance

...therapies to treat non-alcoholic steatohepatitis. Cilofexor is a non-steroidal FXR agonist, and firsocostat is an ACAC...
...developers and to inform whether early pediatric assessments are needed. Targets: ACAC (ACC) - Allosteric acetyl-coenzyme A carboxylase...
BioCentury | Nov 27, 2019
Product Development

Early Pfizer data from DGAT2-targeting NASH program lay groundwork for monotherapy and combos

...compounds. Tropifexor is an agonist of the bile acid receptor FXR. Targets ACC (ACAC) - Acetyl-Coenzyme A carboxylase...
BioCentury | Oct 25, 2019
Tools & Techniques

NASH: how non-invasive biomarkers promise to displace biopsies

...response in an exploratory context. ATLAS is testing monotherapy and combinations of ASK1 inhibitor selonsertib, ACAC...
...trial is “a generic treatment that people know helps with NASH.” Targets ACAC (ACC) - Acetyl-Coenzyme A carboxylase...
...1 Allison Johnson, Senior Writer selonsertib (GS-4997) firsocostat (GS-0976, ndi-010976) cilofexor (GS-9674, px-104) Pfizer Inc. Indalo Therapeutics Inc. Gilead Sciences Inc. Bristol-Myers Squibb Co. FNIH Acetyl-Coenzyme A carboxylase (ACAC) (ACC) Apoptosis...
BioCentury | Jul 2, 2019
Company News

Boehringer races to catch up in NASH through Yuhan deal

...it in a Phase IIa trial in combination with Gilead's non-steroidal FXR agonist cilofexor and ACAC...
...stage trials will need to beat (see "Benchmarks for NASH" ). Targets: ACAC (ACC) - Acetyl-Coenzyme A carboxylase...
BioCentury | Apr 25, 2019
Clinical News

Gilead looks towards NASH combo data after selonsertib fails in second Phase III

...Phase II proof-of-concept trial showing that its non-steroidal FXR agonist cilofexor (GS-9674) in combination with ACAC...
...NASH Targets" ). Gilead was up $1.34 to $64.14 Thursday. Targets: ACAC (ACC) - Allosteric acetyl-coenzyme A carboxylase...
...Li, Staff Writer cilofexor (GS-9674, px-104) firsocostat (GS-0976, ndi-010976) selonsertib (GS-4997) Gilead Sciences Inc. insitro Inc. PathAI Inc Scholar Rock Holding Corp. Yuhan Corp. Acetyl-Coenzyme A carboxylase (ACAC) (ACC) Apoptosis...
BioCentury | Apr 12, 2019
Company News

Gilead, Novo team up to combine NASH compounds

...of combinations for NASH. Cilofexor (GS-9674) is an FXR agonist and firsocostat (GS-0976) is an ACAC...
...are believed to alter all three pathways in NASH, including inflammation, metabolism and fibrosis, while ACAC...
...New York on Friday, and lost DKK4.95 to DKK333.85 in Copenhagen. Targets: ACAC (ACC) - Acetyl-Coenzyme A carboxylase...
BioCentury | Apr 11, 2019
Clinical News

Gilead’s NASH combo data suggest benefit, safety

...Continue to Fuel Investor Concerns” ). Ocaliva and cilofexor are FXR agonists; firsocostat is an ACAC...
...are believed to alter all three pathways in NASH, including inflammation, metabolism and fibrosis, while ACAC...
...to $66.31 on Thursday, while Madrigal lost $14.55 (10%) to $127.95. Targets: ACAC (ACC) - Acetyl-Coenzyme A carboxylase...
BioCentury | Feb 15, 2019
Clinical News

Gilead’s selonsertib fails Phase III for NASH compensated cirrhosis

...Phase II non-steroidal farnesoid X receptor (FXR; NR1H4) agonist GS-9674 and the Phase II acetyl-Coenzyme A carboxylase (ACAC...
...NASH at week 48 Status: Phase III data Milestone: NA Hongjiang Li GS-0976, ndi-010976 GS-9674, px-104 selonsertib (GS-4997) Gilead Sciences Inc. Acetyl-Coenzyme A carboxylase (ACAC) (ACC) Apoptosis...
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