BioCentury | Oct 27, 2016
Distillery Therapeutics


INDICATION: Prostate cancer Cell culture studies identified an inhibitor of the AKAP13 - RHOA interaction that could help treat prostate cancer. Virtual screening of a compound library and in vitro testing of hits yielded a oxopyrazole-furan...
BioCentury | Feb 13, 2014
Tools & Techniques

Micromanaging the microenvironment

A Massachusetts team has designed an in vivo shRNA screen to discover immunosuppressive tumor targets that can be blocked to improve the efficacy of T cell immunotherapies. 1 The screening system shows that current checkpoint...
BioCentury | Aug 3, 2009
Company News

Alexis Biotech, Immunomedics deal The DNL platform uses the docking interaction between Protein kinase A (PKA) and A-kinase anchoring proteins (AKAPs...
BioCentury | May 1, 2006
Tools & Techniques

Locked and loaded conjugates

...a pair of alpha-helical subunits from cyclic AMP-dependent protein kinase ( PKA ) and A-kinase anchoring proteins (AKAPs...
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