07:00 , Jul 14, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Ubiquitin specific peptidase 18 (USP18; ISG43)

Inflammation INDICATION: Inflammatory disease Patient sample studies suggest promoting USP18 expression could help treat type I interferonopathies. DNA sequencing of postmortem fibroblast samples from five neonatal patients with type I interferonopathies identified two loss-of-function mutations...
07:00 , Jun 30, 2016 |  BC Innovations  |  Translation in Brief

Inverted immunity

A cohort of interferon-stimulated gene 15 ( ISG15 )-deficient adolescents has revealed the protein has opposite roles in the viral immunities of mice and humans, and produced data suggesting inhibitors could provide a broad therapeutic...
08:00 , Mar 5, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Interferon-stimulated gene 15 (ISG15); ubiquitin specific peptidase 18 (USP18; ISG43)

Infectious disease INDICATION: Viral infection Mouse studies suggest inhibiting the protease activity of USP18 could help treat viral infections. USP18 downregulates ISG15 , which plays a role in interferon (IFN)-mediated responses to viral infection, but...