07:00 , Apr 16, 2015 |  BC Innovations  |  Distillery Techniques

Techniques: Structure of borrelidin in complex with threonyl tRNA synthetase (TARS;ThrRS)

Drug platforms TECHNOLOGY: Crystal structures Crystal structure analyses of the aminoacyl-tRNA synthetase inhibitor borrelidin complexed with human and bacterial ThrRS could guide the development of borrelidin derivatives with anti-cancer activity. The co-crystal structure showed borrelidin...
08:00 , Feb 5, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Threonyl tRNA synthetase (TARS; ThrRS)

Infectious disease INDICATION: Malaria In vitro and mouse studies have identified derivatives of the aminoacyl-tRNA synthetase inhibitor borrelidin that could help treat malaria infections. A screen of biosynthetically engineered derivatives of borrelidin that had lower...