23:32 , Sep 14, 2018 |  BC Extra  |  Preclinical News

UCSD researchers identify mechanism, target in NASH

Researchers from the University of California San Diego have identified a key mechanism behind the pathogenesis of non-alcoholic steatohepatitis (NASH), which could lead to a therapeutic approach and biomarkers of disease progression. Caspases are suspected...
07:00 , Jun 9, 2011 |  BC Innovations  |  Targets & Mechanisms

Nuclear receptor in the crosshairs of diabetes

Researchers at the Baylor College of Medicine and Scripps Florida have identified a new signaling pathway that could be targeted to treat type 2 diabetes. 1 The group has shown that activating the nuclear receptor...
08:00 , Dec 17, 2009 |  BC Innovations  |  Targets & Mechanisms

Deprogramming stroke

Canadian researchers have taken an entirely new tack on preventing neurotoxicity in acute ischemic stroke by targeting a pathway previously linked to cholesterol metabolism. 1 The University of British Columbia team suggests that a set...
08:00 , Dec 17, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Stroke Sterol regulatory element binding transcription factor 1 (SREBF1; SREBP1); insulin induced gene 1 (INSIG1) Studies in cell culture and in rats suggest that antagonizing...