22:23 , Mar 23, 2018 |  BC Extra  |  Preclinical News

Paper reveals tissue-specificity of cancer growth genes

A study led by Harvard Medical School and Brigham and Women’s Hospital researchers published in Cell showed genes underlying cancer proliferation perform in a tissue-specific manner, potentially presenting a new development paradigm for targeted cancer...
19:58 , Sep 21, 2017 |  BC Innovations  |  Tools & Techniques

On your marks

With less fanfare than the first two waves, a quiet rise in activity is driving a revival of interest in epigenetics, despite little progress in solving the fundamental challenges that have dogged the field from...
19:31 , Sep 11, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Endometrial cancer; prostate cancer Cell culture and mouse studies suggest BET bromodomain proteins inhibitors could help treat SPOP -mutant endometrial cancer and mutant or wild-type SPOP prostate cancers. In a human endometrial cancer cell...
19:13 , Aug 18, 2017 |  BC Extra  |  Preclinical News

Researchers identify 21 new cancer targets

In a paper published in Science , researchers at KTH-Royal Institute of Technology and three Swedish institutes analyzed the transcriptome of 17 major cancer types and identified 32 potential targets that could be inhibited to...
15:24 , Aug 14, 2017 |  BC Extra  |  Preclinical News

Papers uncover predictive markers for BET inhibitor responses

A trio of papers published in Nature Medicine today challenge the notion that similar mutations in the same gene can predict the same drug responses across different types of cancer. While two separate teams of...
07:00 , Jun 7, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Prostate cancer Speckle-type POZ protein (SPOP) Patient sample and cell culture studies suggest SPOP could be useful as a marker for...
07:00 , Mar 12, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Renal cell carcinoma (RCC); clear cell RCC Speckle-type POZ protein (SPOP); c-jun N-terminal kinase (MAPK8; JNK) Studies in human cell culture...