18:21 , Oct 18, 2018 |  BC Innovations  |  Distillery Techniques

Biomarkers; other

TECHNOLOGY: Tissue markers; computational models A computational model based on urine levels of 10 mRNA splice variants could help diagnose DM1. Transcriptomic analysis of cell-free RNA in urine samples from 36 DM1 patients, 28 healthy...
19:57 , Mar 14, 2017 |  BC Week In Review  |  Company News

Boehringer Ingelheim, Vanderbilt University deal

Boehringer and Vanderbilt partnered to research and develop small molecules to treat cancer that target a son of sevenless (SOS) protein, which Boehringer says activates K-Ras (KRAS) . There are two SOS homologs; Boehringer declined...
08:00 , Feb 12, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: K-Ras (KRAS); son of sevenless homolog 1 (SOS1)

Cancer INDICATION: Cancer In vitro studies have identified stapled peptide-based inhibitors of KRAS that could help treat cancer. In a KRAS binding assay, a stapled peptide based on the α-helix of SOS1 bound wild-type and...
07:00 , Jun 20, 2013 |  BC Innovations  |  Cover Story

Interfacing with Ras

A German team has identified a compound that disrupts a protein-protein interaction that localizes K-Ras to the cell membrane, thus inhibiting tumor growth. 1 The interface provides a new small molecule binding site for the...
07:00 , May 16, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer K-Ras; son of sevenless homolog 1 (SOS1); CRAF (RAF1) In vitro, cell culture and mouse studies identified small molecule K-Ras...
07:00 , May 16, 2013 |  BC Innovations  |  Targets & Mechanisms

Raising the Ras inhibitor bar

About a year after U.S. researchers developed small molecule inhibitors of the intractable target wild-type Ras , a Japanese team has identified compounds that hit Ras mutant tumors in mice. 1 The team now is...
07:00 , May 24, 2012 |  BC Innovations  |  Cover Story

Reviving Ras

Activated Ras proteins are among the most notorious oncoproteins, but thus far they have proven undruggable. Now, teams at Roche 's Genentech Inc. unit and at Vanderbilt University School of Medicine have independently used fragment-based...
07:00 , May 24, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer K-Ras; son of sevenless homolog 1 (SOS1) Two independent in vitro studies identified a previously unknown binding site on K-Ras that could be targeted...
07:00 , Mar 31, 2008 |  BioCentury  |  Regulation

EGFR pathway

EGFR pathway Vectibix panitumumab and other epidermal growth factor (EGF) receptor inhibitors are intended to prevent the growth and survival of cells that express EGFR. However, the Ras pathway is downstream of EGFR, so if...