16:41 , Jun 14, 2017 |  BC Innovations  |  Distillery Therapeutics

Hematology

INDICATION: Anemia; hematology Cell culture and zebrafish studies suggest the iron-binding small molecule hinokitiol could help treat anemia and ferroportin disease, an iron overload disease caused by loss-of-function SLC40A1 mutations. In mouse erythroleukemia cells deficient...
21:45 , Jun 8, 2017 |  BC Innovations  |  Targets & Mechanisms

Pumping iron

A natural compound from the Japanese Hinoki tree may hold the answer to iron transport diseases treated inadequately by phlebotomy, chelation therapy or dietary supplements. In Science last month, a University of Illinois -led group...
07:00 , Apr 16, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Hematology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Hematology Anemia; hemochromatosis Hypoxia-inducible factor 2a (EPAS1; HIF2A); solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (SLC11A2; DMT1) Studies...
08:00 , Nov 20, 2008 |  BC Innovations  |  Cover Story

Figure 1. Iron in Parkinson's disease

Figure 1. Iron in Parkinson's disease Figure 1. Iron in Parkinson's disease. Targeting iron or iron-related reactions in the neuron could lead to potential treatments in Parkinson's disease (PD). Salazar et al . suggest that...
08:00 , Nov 20, 2008 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Parkinson's disease (PD) Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (SLC11A2; DMT1) A study in human tissue,...
08:00 , Nov 20, 2008 |  BC Innovations  |  Cover Story

Testing Parkinson's metal

The search for disease-modifying therapeutics in Parkinson's disease has been stymied by a lack of consensus about whether the disease is caused by free radical formation, protein aggregation or mitochondrial dysfunction. Now, a pair of...