07:00 , Jun 4, 2015 |  BC Innovations  |  Distillery Techniques

Techniques: Direct conversion of fibroblasts to osteoblasts for bone regeneration

Drug platforms TECHNOLOGY: Cell therapy Fibroblasts directly converted to osteoblasts could be used to promote bone regeneration. The method transformed human gingival fibroblasts to cells that expressed multiple osteoblast-related transcripts using a viral vector encoding...
08:00 , Dec 11, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Musculoskeletal disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Musculoskeletal disease Bone repair N-terminal acetyltransferase complex ARD1 subunit homolog A (NAA10; ARD1A; ARD1); runt-related transcription factor 2 (RUNX2) In vitro and rodent studies suggest inhibiting...
07:00 , Sep 4, 2008 |  BC Innovations  |  Tools & Techniques

Smooth Grafts Ahead

Researchers at the Georgia Institute of Technology have developed an approach to address a major problem with synthetic tissue grafts: poor integration with host tissue. The group used polymer-immobilized retroviruses to control cell differentiation and...
07:00 , Aug 21, 2008 |  BC Innovations  |  Distillery Techniques

This Week in Techniques

This week in techniques Approach Summary Licensing status Publication and contact information Graded osteoclast interfaces for tissue engineering Retrovirus-directed cell differentiation may be useful for engineering tissues that better resemble native tissue. Fibroblasts were seeded...