01:01 , May 7, 2019 |  BC Innovations  |  Distillery Techniques

Expression of multigene panels in CNS cell types as markers of early AD

TECHNIQUES CATEGORY: Biomarkers TECHNOLOGY: Gene profiling; tissue markers Gene expression profiling in neurons, oligodendrocytes, microglia and other CNS cell types could help diagnose early Alzheimer's disease. In post-mortem prefrontal cortex samples AD patient and unaffected...
19:35 , Feb 13, 2019 |  BC Innovations  |  Distillery Therapeutics

Autoimmune disease

INDICATION: Osteoarthritis Patient sample and mouse studies suggest inhibiting the CH25H-RORA axis could help treat osteoarthritis. In patients, mRNA and protein levels of CH25H and RORA, two factors on the cholesterol metabolism pathway in chondrocytes,...
22:33 , Jul 11, 2017 |  BC Extra  |  Preclinical News

Team identifies RORA as potential NASH target

In a paper published in Cell Reports , researchers at Seoul National University showed retinoid-related orphan receptor alpha ( RORA ) regulated polarization of liver macrophages to protect against non-alcoholic steatohepatitis, and suggested activation of...
07:00 , Sep 10, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: RAR-related orphan receptor A (RORA)

Ophthalmic disease INDICATION: Age-related macular degeneration (AMD) Mouse studies suggest inhibiting RORA could help treat AMD. In a mouse model of oxygen-induced retinopathy, 75% oxygen increased RORA expression in retinas compared with normal air, and...
07:00 , Mar 15, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Breast cancer RAR-related orphan receptor A (RORA); semaphorin 3F (SEMA3F) Mouse and patient sample studies suggest increasing RORA signaling through SEMA3F could treat breast cancer....
07:00 , Apr 28, 2011 |  BC Innovations  |  Cover Story

Immune dampening at the source

Two U.S. academic groups have separately identified small molecule RAR-related orphan receptor inhibitors that block production of proinflammatory T helper type 17 cells and decrease disease severity in a mouse model of multiple sclerosis. 1,2...
07:00 , Apr 28, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Autoimmune disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Autoimmune disease Autoimmune; multiple sclerosis (MS) RAR-related orphan receptor A (RORA); RORC (RORg; RORgT); IL-17 (IL-17A) A study in cell culture and...
08:00 , Feb 11, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Colorectal cancer RAR-related orphan receptor A (RORA) Studies in cell culture and in patient tumor tissue samples suggest that increasing RORA phosphorylation could help treat...
08:00 , Dec 18, 2008 |  BC Innovations  |  Distillery Therapeutics

This week in therapeutics

The Distillery: Therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Metabolic disease Von Gierke's disease Glucose-6-phosphatase catalytic subunit (G6PC; G6Pase); nuclear receptor coactivator 2 (NCOA2; SRC2); RAR-related orphan receptor-a (RORa) Studies in mice...