07:00 , Mar 14, 2013 |  BC Innovations  |  Targets & Mechanisms

Placing kinases in the WNT pathway

Despite the well-established role of WNT signaling in many cancers, the pathway has proven difficult to modulate therapeutically because it is largely composed of hard-to-target protein-protein interactions. Now, a Boston-based team and a group led...
08:00 , Feb 28, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Receptor-interacting serine-threonine kinase 4 (RIPK4; RIP4) Studies in cell culture, mice and human tissue samples suggest inhibiting RIPK4 could help treat cancers driven by...