02:16 , Apr 5, 2019 |  BC Innovations  |  Targets & Mechanisms

Breaking up Hippo to tame proliferation

Drug developers are creating a new class of compounds that disrupt a protein-protein interaction in the Hippo pathway that goes awry in cancers and fibrotic diseases. At least two programs are poised to enter the...
04:15 , Apr 13, 2018 |  BC Innovations  |  Targets & Mechanisms

Hello RNA

BioCentury’s analysis of new and emerging targets presented at this year’s AACR meeting reveals a surge in activity in non-coding RNAs, as researchers continue to expand target space. The results also reflect the ongoing high...
03:45 , Apr 13, 2018 |  BC Innovations  |  Targets & Mechanisms

Meeting the burden

A major theme at this year’s AACR is the abundance of preclinical discovery driven by molecular signatures in patient samples, suggesting the research community is heeding the call for studies better grounded in human data,...
22:54 , Sep 14, 2017 |  BC Innovations  |  Targets & Mechanisms

Platelets YAP at cancer

While elevated platelet levels often signify an underlying malignancy, the molecular mechanisms linking the two are not well understood. Now, a team from MD Anderson has shown a well-known, but barely exploited signaling pathway mediates...
07:00 , Oct 27, 2016 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Prostate cancer Cell culture studies identified an inhibitor of the AKAP13 - RHOA interaction that could help treat prostate cancer. Virtual screening of a compound library and in vitro testing of hits yielded a...
07:00 , Oct 9, 2014 |  BC Innovations  |  Targets & Mechanisms

Ral-lying around Ras

Most efforts to inhibit Ras have focused on its downstream MEK- or phosphoinositide 3-kinase-mediated pathways because blocking Ras directly is complicated by the lack of drug-binding pockets on the enzyme. A University of Colorado Denver...
07:00 , Aug 21, 2014 |  BC Innovations  |  Distillery Techniques

Technology: Markers

Approach Summary Licensing status Publication and contact information Markers Gastric tumor classification system Studies in patient samples have identified a classification system for human gastric cancers that could help guide treatment decisions. Molecular and genetic...
08:00 , Feb 6, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Pulmonary disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Pulmonary disease Respiratory distress syndrome (RDS) Ras homolog family member A (RHOA) Cell culture and mouse studies suggest blocking nitration of RHOA could help treat acute...
08:00 , Feb 14, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Ras homolog gene family member A (RHOA); leukemia-associated Rho guanine nucleotide exchange factor (LARG) In vitro studies identified a small molecule inhibitor of the...
08:00 , Nov 17, 2011 |  BC Innovations  |  Targets & Mechanisms

SEMA4D in osteoporosis

Researchers from the Tokyo Medical and Dental University have shown that inhibition of the protein semaphorin 4D increases bone formation in a mouse model of osteoporosis. 1 By directly promoting bone formation, a semaphorin inhibitor...