23:38 , Jul 24, 2018 |  BC Innovations  |  Distillery Techniques

Assays and screens

TECHNOLOGY: Binding assays; cellular assays A screening method using non-coding SNPs from genome-wide association studies (GWAS) could help identify new drug targets. The method involves five steps: creating double-stranded 31-base pair DNA constructs with each...
02:11 , Dec 8, 2017 |  BC Innovations  |  Targets & Mechanisms

Pathways emerging from ASH

A survey of the emerging molecular targets at this year’s American Society of Hematology conference indicates that while harnessing the immune system to treat cancer remains a dominant interest, processes for tuning protein levels --...
07:00 , Aug 4, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Recombination signal binding protein for immunoglobulin κ J region (RBPJ; CBF1)

Cardiovascular disease INDICATION: Myocardial infarction (MI) Mouse studies suggest inhibiting RBPJ could help treat MI. In a mouse model of MI, cardiomyocyte-specific knockout of RBPJ increased cardiac function and decreased morphological defects and fibrotic scar...
07:00 , Oct 28, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Renal disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Renal disease Renal damage; end-stage renal disease (ESRD) Notch homolog 1 translocation-associated (NOTCH1); recombination signal binding protein for immunoglobulin k-J region (RBPJ; CBF1) Studies in mice...
07:00 , Apr 2, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Acute megakaryoblastic leukemia (AMKL) One twenty-two protein (RBM15; OTT); megakaryocytic acute leukemia (MKL1; MAL); myeloproliferative leukemia virus oncogene (MPL); recombination signal...
07:00 , Apr 19, 1999 |  BC Week In Review  |  Clinical News

Mendel regulatory update

U.S. Patent No. 5,891,859 issued to Michigan State University covering a method of regulating the expression of cold and dehydration-regulated genes in a plant by transforming the plant with the CBF1 transcription factor. Mendel has...