16:05 , Aug 16, 2018 |  BC Innovations  |  Distillery Therapeutics

Gastrointestinal

INDICATION: Gastrointestinal Mouse studies suggest inhibiting JAK-1 and JAK-2, RAG2 or IL-6 could help treat Peutz-Jeghers syndrome, which involves the formation of benign gastrointestinal polyps. In a mouse model of the disease, systemic knockout of...
08:00 , Mar 10, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Recombination activating gene 2 (RAG2)

Autoimmune disease INDICATION: Immunodeficiency Mouse studies suggest antibiotics plus fecal transplants could help treat Omenn syndrome, a form of severe combined immunodeficiency associated with mutations in recombination activating genes (RAGs). In a RAG2-mutant mouse model...
07:00 , Jun 5, 2014 |  BC Innovations  |  Distillery Techniques

Technology: Disease models

Approach Summary Licensing status Publication and contact information Disease models Recombination activating gene 2 (RAG2) knockout pigs to model immunodeficiency and evaluate transplant-based therapies Pigs with RAG2 knocked out could be useful as models of...
07:00 , Sep 27, 2012 |  BC Innovations  |  Distillery Techniques

Technology: Disease models

Approach Summary Licensing status Publication and contact information Disease models Humanized mouse model for liver-stage malaria infection Mice with humanized livers could be useful for identifying compounds that target the liver stage of human malarial...
07:00 , Sep 27, 2012 |  BC Innovations  |  Tools & Techniques

Humanizing malaria mice

U.S. researchers have developed the first mouse model that recapitulates the human stages of the malarial parasite Plasmodium falciparum life cycle in one animal. 1 The academics plan to make additional modifications to the mice...
07:00 , Jul 19, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Hematology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Hematology Immunodeficiency CD3e molecule-e CD3-TCR complex (CD3E) Mouse studies suggest anti-CD3E mAbs could help treat Omenn syndrome, a form of severe combined...
07:00 , Nov 4, 2010 |  BC Innovations  |  Distillery Techniques

Technology: Disease models

This week in techniques Approach Summary Licensing status Publication and contact information Disease models Mouse model of Salmonella typhi infection Immunodeficient mice engrafted with human hematopoietic stem cells could be useful models of typhoid fever....
07:00 , Sep 10, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/ pathway Summary Licensing status Publication and contact information Cancer Colon cancer T-box 21 (TBX21; T-bet); recombination activating gene 2 (RAG2) Studies in mice suggest that agonizing T-bet could help prevent colitis-associated colorectal cancer....
07:00 , Aug 21, 2008 |  BC Innovations  |  Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Cancer Leukemia Phosphoinositide 3-kinase-d (PI3Kd); recombination activating gene 2 (RAG2) Studies in mice and in cell culture suggest that inhibiting PI3Kd...
08:00 , Mar 18, 2002 |  BC Week In Review  |  Company News

The Whitehead Institute for Biomedical Research other research news

Researchers published in Cell evidence that nuclear transfer technology can be used to treat certain genetic defects. The researchers created ESCs by nuclear transfer using cells from a severe combined immunodeficiency (SCID) mouse, which lacks...