22:40 , Jun 5, 2018 |  BC Innovations  |  Distillery Techniques

Drug delivery

TECHNOLOGY: Targeting domains; other Circular single-stranded DNA (CSSD)-based PTK7-targeting aptamers could be used to deliver cancer therapies. The aptamers consist of CSSD engineered to target PTK7 -- a protein expressed on many cancers -- and...
17:39 , Jan 25, 2017 |  BC Innovations  |  Distillery Techniques

Drug delivery

TECHNOLOGY: Targeting domains A DNA-based “lock-and-key” system that targets pairs of receptors could be used for cell type-specific delivery of therapeutic siRNAs. The system consisted of a hairpin DNA “key” and two receptor-specific aptamer “locks,”...
17:34 , Nov 4, 2016 |  BC Week In Review  |  Clinical News

PF-06647020: Ph I data

Data from 22 evaluable patients with recurrent ovarian cancer in the dose-expansion portion of an open-label, U.S. and Spanish Phase I trial showed that the recommended Phase II dose of 2.8 mg/kg IV PF-06647020 every...
07:00 , Jun 13, 2016 |  BioCentury  |  Product Development

Small cell synergy

Investors and others watching data coming from the American Society of Clinical Oncology meeting were quick to pan overall survival data from a Phase I study of single-agent Rova-T rovalpituzumab tesirine in recurrent small cell...
07:00 , Apr 24, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Non-small cell lung cancer (NSCLC) PTK7 protein tyrosine kinase 7 (PTK7; CCK4) Studies in mice and patient samples suggest inhibiting PTK7 could be useful for...
07:00 , Mar 17, 2011 |  BC Innovations  |  Cover Story

Imaging with aptamers

Researchers at Hunan University have developed a method for synthesizing aptamer probes that fluoresce only when bound to their target. 1 The group thinks its approach could be used to generate aptamers that improve the...
08:00 , Mar 10, 2011 |  BC Innovations  |  Distillery Techniques

Technology: Imaging

Approach Summary Licensing status Publication and contact information Imaging Aptamer probes for in vivo cancer imaging Aptamer probes could be useful for cancer cell-specific imaging. In vitro selection methods identified an aptamer that emitted a...
07:00 , Jul 15, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Acute myelogenous leukemia (AML) PTK7 protein tyrosine kinase 7 (PTK7) In vitro studies suggest that inhibiting PTK7 could help treat AML. About 72% of blood...