03:31 , Dec 7, 2018 |  BC Innovations  |  Tools & Techniques

Germline editing gets technical

As the smoke clears from Jiankui He’s bombshell germline editing announcement, the gap between where the gene editing field is now and where it would need to be to support responsible germline editing has become...
21:14 , Sep 27, 2017 |  BC Innovations  |  Translation in Brief

Editing without translation

While last week’s Nature paper on gene editing of human embryos was a first in the U.K., it was more notable for the ground it broke than for its translational implications. Earlier studies from U.S....
07:00 , May 12, 2016 |  BC Innovations  |  Tools & Techniques

Modeling with interference

While much of the focus on CRISPR-based gene editing has been on its potential to change the way genetic disorders are treated, the biggest and most immediate impact of the rapidly emerging technology so far...
07:00 , May 12, 2016 |  BC Innovations  |  Distillery Techniques

Techniques: Nine-compound cocktails to induce differentiation of fibroblasts into cardiomyocyte-like or neural stem cell-like cells for regenerative therapies

Drug platforms TECHNOLOGY: Cell therapy Two different nine-compound cocktails could enable direct reprogramming of fibroblasts into cardiomyocyte-like cells or neural stem cell-like cells for use in regenerative therapies. In human fibroblasts, administration of one cocktail...
07:00 , Apr 7, 2016 |  BC Innovations  |  Finance

Public Funding Notebook: Transparency from outside

NIH's new deputy director for extramural research has set improving transparency as his banner priority, focusing in particular on the process for awarding grants and accountability over public funds. Michael Lauer, who replaced Sally Rockey...
07:00 , Jun 11, 2015 |  BC Innovations  |  Distillery Techniques

Techniques: Blood-derived induced neuronal progenitor (iNP) cells

Disease models TECHNOLOGY: Cell models Blood-derived iNP cells could be used to develop in vitro and in vivo models of neurological diseases. Human neonatal or adult peripheral blood cells were converted to iNP cells using...
07:00 , Jun 4, 2015 |  BC Innovations  |  Distillery Techniques

Techniques: Direct conversion of fibroblasts to osteoblasts for bone regeneration

Drug platforms TECHNOLOGY: Cell therapy Fibroblasts directly converted to osteoblasts could be used to promote bone regeneration. The method transformed human gingival fibroblasts to cells that expressed multiple osteoblast-related transcripts using a viral vector encoding...
07:00 , Apr 3, 2014 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

Approach Summary Licensing status Publication and contact information Drug platforms Mouse cardiomyocytes generated from fibroblasts with one pluripotency factor and four small molecules Cell culture studies suggest cardiomyocytes for use in pharmacological screening and regenerative...
07:00 , Mar 20, 2014 |  BC Innovations  |  Cover Story

A liver divided

Three separate teams have directly converted human fibroblasts to proliferative liver cells and thus eliminated a key drawback of using induced pluripotent stem cells to treat damaged livers-the inability of the resulting differentiated cells to...
08:00 , Feb 27, 2014 |  BC Innovations  |  Tools & Techniques

(Pluri)potent acid

Academics and companies alike are scrambling-and thus far failing-to reproduce a surprisingly simple method for generating pluripotent mouse stem cells that uses an external stress stimulus to trigger reprogramming. Whether the method simply does not...