21:15 , Mar 5, 2019 |  BC Innovations  |  Distillery Techniques

Vascularized kidney organoids for modeling renal disease

TECHNIQUES CATEGORY: Disease models TECHNOLOGY: 3-D models Vascularized kidney organoids could be used to study kidney development and model renal diseases. The organoids are generated in three steps: culturing human pluripotent stem cells with fibroblast...
07:00 , Apr 17, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Various

Indication Target/marker/pathway Summary Licensing status Publication and contact information Various Autoimmune disease; inflammation Platelet/endothelial cell adhesion molecule 1 (PECAM1; CD31) In vitro and mouse studies suggest increasing CD31 signaling could help treat inflammatory and autoimmune...
07:00 , Apr 3, 2014 |  BC Innovations  |  Targets & Mechanisms

Narrowing down graft stenosis

One of the dominant problems after coronary artery bypass graft surgery is hyperplastic growth inside the transplanted blood vessel that can lead to stenosis. Now, a team at the NIH 's National Heart, Lung, and...
08:00 , Nov 14, 2011 |  BC Week In Review  |  Clinical News

Atu134: Development discontinued

Silence discontinued development of preclinical candidate Atu134 after concluding its potential clinical profile is too similar to Atu027 to warrant development of both compounds. Atu027, a liposomal siRNA formulation targeting protein kinase N3 (PKN3) ,...
07:00 , Oct 21, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Platelet/endothelial cell adhesion molecule (PECAM1; CD31) A study in mice suggests that inhibiting PECAM1 could help treat advanced metastatic cancer. In mouse models of...
08:00 , Apr 1, 2002 |  BC Week In Review  |  Company News

Massachusetts Institute of Technology other research news

Researchers published in the Proceedings of the National Academy of Sciences that hESCs are able to differentiate into functional endothelial cells. Endothelial cells were isolated from a hESC clonal line using antibodies that target the...
07:00 , May 29, 2001 |  BC Week In Review  |  Company News

University of Miami other research news

University researchers published in Neurology that the plasma of MS patients has more EMPs and CD31 than healthy controls, as measured by flow cytometry. EMPs are a marker of endothelial dysfunction that can contribute to...