16:13 , Aug 16, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Pain Mouse and rat studies suggest inhibiting PANX1 or its activator P2RX7 in spinal microglia, or an antibody-drug conjugate (ADC) targeting the microglia, could help treat joint pain. In spinal cord samples from a...
22:54 , Jan 31, 2017 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Addiction Mouse and rat studies suggest inhibiting PANX1 could help treat opiate withdrawal. In two mouse models of morphine withdrawal, spinal microglia-specific knockout of PANX1 or probenecid, which inhibits PANX1, decreased withdrawal behaviors compared...
23:43 , Jan 30, 2017 |  BC Extra  |  Clinical News

Paper ties opioid withdrawal to new target

In a paper published Monday in Nature Medicine, researchers suggested that inhibiting pannexin 1 (PANX1) could help treat opiate withdrawal. The group was led by University of Calgary Assistant Professor Tuan Trang. BioCentury's BCIQ database...
07:00 , Apr 10, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Bacterial infection Pannexin 1 (PANX1) In vitro studies suggest avoiding PANX1 inhibition could prevent the toxic side effects of some quinolone antibiotics. Pfizer Inc.'s...
07:00 , Mar 14, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Migraine; pain Caspase-1 (CASP1); high mobility group box 1 (HMGB1); NF-kB; pannexin 1 (PANX1) Mouse studies suggest inhibiting PANX1 in neurons could help treat migraine...
08:00 , Jan 5, 2012 |  BC Innovations  |  Cover Story

No place like inflammasome

Researchers at Virginia Commonwealth University have found that inhibiting inflammasome formation with antagonists of the membrane receptor P2X7 could help prevent heart failure following acute myocardial infarction. 1 The findings point to a repurposing opportunity...
07:00 , Sep 15, 2011 |  BC Innovations  |  Cover Story

New targets for HIV

The mechanisms by which HIV binds to and fuses with host cells are well documented, but the pathway mediating the intermediate steps between binding and fusion is murky. Now, researchers in France and Italy have...
07:00 , Sep 8, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease HIV/AIDS Pannexin 1 (PANX1); purinergic receptor P2Y G protein-coupled 2 (P2RY2; P2Y2); protein tyrosine kinase 2b (PTK2B; PYK2) Cell culture studies suggest inhibiting purinergic...
07:00 , Apr 14, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Alzheimer's disease (AD) Gap junction protein a1 43 kDa (GJA1; CX43); pannexin 1 (PANX1) Cell culture and electrophysiological studies suggest that antagonizing CX43 and PANX1...
08:00 , Jan 8, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Neurology Epilepsy; stroke Pannexin 1 (PANX1); N-methyl-d-aspartic acid receptor (NMDA receptor) Studies in cell culture and in brain slices suggest that...