18:03 , Oct 25, 2018 |  BC Innovations  |  Distillery Techniques

Biomarkers

TECHNOLOGY: Tissue markers The percentage of bone marrow-disseminated tumor cells with high NR2F1 levels could help predict bone metastasis and survival in breast cancer. In 26 breast cancer patients, high NR2F1 expression in less than...
17:04 , Jul 18, 2018 |  BC Innovations  |  Translation in Brief

Playing chicken with metastasis

In a June study published in Nature Communications , a University of Alberta team described an in vivo screen that identified genetic drivers of cancer metastasis, and the university has spun out Entos Pharmaceuticals Inc....
15:41 , Jul 18, 2018 |  BC Innovations  |  Distillery Techniques

Assays and screens

TECHNOLOGY: Cellular assays A chicken embryo-based method of screening genes required for tumor cell motility could identify new targets for cancer metastasis. The method involves six steps: transducing metastatic cancer cells with a human shRNA...
08:00 , Feb 12, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Nuclear receptor subfamily 2 group F member 1 (NR2F1; COUP-TFI)

Cancer INDICATION: Cancer Studies in cell culture, mice and patient samples suggest activating NR2F1 could help prevent cancer metastasis by inducing tumor dormancy. In patient-derived disseminated prostate tumor cells and a human cell line of...