19:27 , Sep 10, 2018 |  BC Innovations  |  Distillery Techniques

Disease models

TECHNOLOGY: Transgenics and knockouts PGK1-knockout mice expressing an SP-C variant could be used to study the biology of idiopathic pulmonary fibrosis (IPF) and screen for therapies. Mice with inducible knockout of PGK1 that systemically expressed...
01:08 , Dec 13, 2017 |  BC Innovations  |  Distillery Therapeutics

Hepatic

INDICATION: Liver disease Patient sample and mouse studies suggest inhibiting MMP7 could help treat biliary atresia, a progressive infantile cholangiopathy. In serum samples from pediatric patients, levels of MMP7 protein were higher than in samples...
08:00 , Feb 5, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Matrix metalloproteinase 7 (MMP7)

Cancer INDICATION: Cancer In vitro studies suggest a gelation-inducing peptide-lipid conjugate activated by MMP7 could help treat cancer. Many cancers express high levels of MMP7. In vitro, MMP7 cleaved the conjugate into nanofibers that self-assembled...
07:00 , Apr 2, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Inflammation

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Inflammation Asthma Matrix metallopeptidase 7 (matrilysin, uterine) (MMP7); IL-25; aldehyde dehydrogenase 1 family, member A1 (ALDH1A1; RALDH1A1) Studies in cell culture and...
08:00 , Dec 11, 2008 |  BC Innovations  |  Distillery Therapeutics

This week in therapeutics

The Distillery: Therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Various cancer indications Matrix metallopeptidase 7 (MMP7); VEGF-A; VEGF; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (FLT1) In...