03:19 , Nov 2, 2018 |  BC Innovations  |  Targets & Mechanisms

FDA’s pediatric target picks

FDA is looking ahead of industry in its guideline on targets for pediatric oncology, which includes more than 50 not yet in company pipelines in a list of over 220 the agency has its eye...
19:22 , Sep 19, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Breast cancer Cell culture and mouse studies suggest inhibiting KDM4A could help treat triple-negative breast cancer (TNBC). In TNBC patients, high levels of KDM4A in tumor samples were associated with poor relapse-free survival. In...
19:01 , May 8, 2017 |  BC Innovations  |  Distillery Techniques

Chemistry

TECHNOLOGY: Tool compounds Three cyclic peptide-based inhibitors of KDM4A , KDM4B and KDM4C could be useful for probing the role of the enzymes in cancer. Screening of a library of thioether-based macrocycles in vitro identified...
08:00 , Dec 10, 2015 |  BC Innovations  |  Distillery Techniques

Techniques: Patient-specific embryonic stem cell (ESC) lines created by somatic cell nuclear transfer and overexpression of lysine-specific demethylase 4A (KDM4

Disease models KDM4A lysine-specific demethylase 4A JMJD2A Harvard Medical School...
07:00 , Aug 21, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Prostate cancer Lysine-specific demethylase 4A (KDM4A; JMJD2A); KDM4B (JMJD2B) Cell culture studies suggest inhibiting KDM4A and KDM4B could help treat prostate cancer. In human prostate...
07:00 , May 30, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Lysine-specific demethylase 4A (KDM4A; JMJD2A); jun (AP1) proto-oncogene Cell culture and mouse studies suggest inhibiting KDM4A could help treat metastatic...
07:00 , Jun 2, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Cardiovascular disease

Indication Target/marker/ pathway Summary Licensing status Publication and contact information Cardiovascular disease Heart failure Lysine (K)-specific demethylase 4A (KDM4A; JMJD2A) Studies in patient samples and in mice suggest inhibiting KDM4A could help treat cardiac hypertrophy....